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CAS No.: 2313526-86-0

VU6012962 is a CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM.

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400-920-2911

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描述Metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system^[1]. Today, eight subtypes of mGluRs (mGluR1-mGluR8) have been cloned and classified into three groups on the basis of sequence similarities, and pharmacological and biochemical properties^[2]. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases^[3]. VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM). Compared to the other seven mGlu receptor subtypes, VU6012962 is highly selective for mGlu7. In the elevated zero maze (EZM) assay in mice, VU6012962 (1-10 mg/kg; i.p.; 60 minutes prior to testing) decreases anxiety in multiple preclinical models^[4].
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CAS号	2313526-86-0	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H19F3N4O4	运输	蓝冰
分子量	448.40	别名

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