|1,6-二甲基-3-(4-(三氟甲基)苯基)嘧啶并[5,4-e][1,2,4]三嗪-5,7(1H,6H)-二酮|CsnPharm

CAS No.: 878419-78-4

Walrycin B is an antibacterial compound specifically targeting the essential WalR response regulator.

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400-920-2911

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描述Walrycin B is a novel antibacterial compound specifically targeting the essential WalR response regulator. The IC50 of Walrycin B was 0.39 ug/mL (MIC for B. subtilis 168); 3.13 ug/mL (MIC for S. aureus N315). Walrycins are a new class of potent small molecule compounds that kill bacterial cells by targeting the RR WalR and inhibiting this essential signal transduction pathway. They not only have therapeutic potential but will also prove to be useful reagents for the further study of the WalK/WalR TCS. Addition of Walrycins simultaneously affects the expression of WalR regulon genes, leading to phenotypes consistent with those of cells starved for the WalK/WalR system and having a bactericidal effect. Walrycin B target WalR and lead to cell death in both B. subtilis and S. aureus. Walrycins A and B are the first antibacterial agents targeting WalR in B. subtilis and S. aureus^[2]. Walrycin B is a WalR inhibitor. Walrycin B did not kill MRSA persisters or induce membrane permeabilization and did not affect GUVs (giant unilamellar vesicles)^[3].
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技术信息

CAS号

878419-78-4

储存条件

分子式

C14H10F3N5O2

运输

蓝冰

分子量

337.26

别名

溶解度

DMSO	24.44 mg/mL (72.5 mM)
Water	insoluble

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