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CAS No.: 632-85-9

Wogonin/汉黄芩素 Catalog No. CSN16440

Synonyms: Vogonin;BRN 0287152;汉黄芩素

Wogonin acts as an inhibitor of COX2 with IC50 of 46 μM without affecting COX-1 and inhibits the NF-κB pathway-mediated iNOs induction. Wogonin can be isolated from the root of scutellaria baicalensis georgi.

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技术信息

生物活性

描述Wogonin, a naturally occurring flavonoid derived from the root extract of Scutellaria baicalensis, used in the treatment of inflammatory diseases. In vivo, treatment of osteoarthritis chondrocytes with Wogonin (10-50 μM) significantly blocked the IL-1β induced production of NO in a dose dependent manner^[3]. Moreover, wogonin protected retinal ganglion cells survival and suppressed neuro-inflammation in retina after optic nerve crush by inhibiting TLR4-NF-κB pathways^[4]. In vitro, DNA intercalation by Wogonin may result in the stabilization of genomic DNA leading to protective activity^[6].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
RAW264.7 cells	-	Function assay	-	Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay, IC50=1.07 μM	19233646
SW1353 cells	-	Function assay	-	Antiinflammatory activity in PMA-stimulated human SW1353 cells assessed as inhibition of NF-kappaB activation, IC50=39 μM	19555121

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

632-85-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

Vogonin;BRN 0287152;汉黄芩素

溶解度

DMSO	55.0 mg/mL (193.5 mM)
Water	Insoluble
Ethanol	3.0 mg/mL (10.6 mM)

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