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CAS No.: 1783977-95-6

Xanthine amine congener HCl Catalog No. CSN24475

Synonyms: XAC hydrochloride;XANTHINE AMINE CONGENER 3HCl

XAC is an adenosine receptor antagonist with IC50 value of 16μM for Adenosine Receptor A2.

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400-920-2911

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技术信息

生物活性

描述Adenosine receptor signaling plays important roles in normal physiology, but is also known to modulate the development or progression of several different diseases ^[1]. XAC 3HCl, a potent adenosine receptor antagonist, was used to block adenosine receptors ^[1]. Mild hypoxia decreased coronary resistance by 37(SEM 4)% in the absence of XAC and 26(5)% or 17(4)% in the presence of 200 or 400 nM XAC, respectively. XAC 400 nM markedly increased (p<0.05) the hypoxic levels of venous and epicardial fluid adenosine from 49(19) and 251(42) nM to 75(11) and 495(48) nM, respectively. XAC 100-200 nM almost completely prevented the vasodilatation induced by 1 μM intracoronary adenosine ^[1].
参考文献

[1] Peleli M, Fredholm BB, Sobrevia L, Carlström M. Pharmacological targeting of adenosine receptor signaling. Mol Aspects Med. 2017 Jun;55:4-8. doi: 10.1016/j.mam.2016.12.002. Epub 2017 Jan 12. PMID: 28088486.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1508 mL
- 10.7539 mL
- 21.5079 mL
- 5 mM
- 0.4302 mL
- 2.1508 mL
- 4.3016 mL
- 10 mM
- 0.2151 mL
- 1.0754 mL
- 2.1508 mL

技术信息

CAS号

1783977-95-6

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H29ClN6O4

运输

蓝冰

分子量

464.95

别名

XAC hydrochloride;XANTHINE AMINE CONGENER 3HCl

溶解度

DMSO	40.0 mg/mL (86.0 mM)
Water	insoluble

动物实验配方

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