CAS No.: 1403898-55-4
XIAP/cIAP1 antagonist-1 Catalog No. CSN20155
Synonyms: AT-IAP
AT-IAP is a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 which is functioning in anti-apoptotic and pro-survival signaling pathways.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Tamanini E, Buck IM, et al. Discovery of a Potent Non-peptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-linked Inhibitor of Apoptosis Protein (XIAP). J Med Chem. 2017 May 11.
- [2] Armstrong CW, Maxwell PJ, et al. PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy. Oncotarget. 2016 Feb 16;7(7):7885-98.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1403898-55-4 | 储存条件 |
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| 分子式 | C29H40FN5O2 | 运输 | 蓝冰 | |
| 分子量 | 509.66 | 别名 | AT-IAP |
