|N-(2-氨基苯基)-4-(1-((1,3-二甲基-1H-吡唑-4-基)甲基)哌啶-4-基)苯甲酰胺|CsnPharm

CAS No.: 934828-12-3

Zabadinostat Catalog No. CSN18936

Synonyms: HDAC-IN-4;AZD-9468

HDAC-IN-4 is a histone deacetylase (HDAC) inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

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实验方案

技术信息

生物活性

描述Histone deacetylases (HDAC) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of histones and non-histone proteins. HDAC inhibitors are a new class of anti-cancer agents that induce apoptosis and cell cycle arrest in cancer cells. CXD-101 is a class I-selective HDAC inhibitor that inhibits HDAC1, HDAC2, and HDAC3 with IC50 values of 63, 570, and 550nM, respectively, and had no activity against class II HDAC^[1]. The IC50 values of CXD-101 in colon, lung, non-Hodgkin lymphoma, and myeloma cell lines ranged from 0.2 to 15μM. In murine lung (A549a) and colon (HT29) models, CXD-101 reduced tumor size at a dose of 50mg/kg, which was found to be associated with decreased HDAC enzyme activity and increased histone acetylation^[2].

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4782 mL
- 12.3910 mL
- 24.7819 mL
- 5 mM
- 0.4956 mL
- 2.4782 mL
- 4.9564 mL
- 10 mM
- 0.2478 mL
- 1.2391 mL
- 2.4782 mL

技术信息

CAS号

934828-12-3

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H29N5O

运输

蓝冰

分子量

403.52

别名

HDAC-IN-4;AZD-9468

溶解度

DMSO	160.0 mg/mL (396.5 mM)
Water	insoluble

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