|AEZS-108|CsnPharm

CAS No.: 139570-93-7

Zoptarelin doxorubicin Catalog No. CSN20400

Synonyms: Zoptarelin Doxorubicin;AN 152;AEZS-108

AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).

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技术信息

生物活性

描述AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01240629	Prostate Cancer ... more >> Hormone-resistant Prostate Cancer Recurrent Prostate Cancer Stage IV Prostate Cancer Collapse <<	Phase 1 Phase 2	Completed	-	United States, California ... more >> University of Southern California Los Angeles, California, United States, 90033-0804 Collapse <<
NCT01234519	Urothelial Carcinoma	Phase 1 Phase 2	Terminated(Poor recruitment)	-	United States, Florida ... more >> University of Miami Miller School of Medicine Miami, Florida, United States, 33136 United States, Pennsylvania Univerity of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT01698281	Breast Cancer	Phase 2	Terminated(Poor recruitment)	-	United States, Florida ... more >> University of Miami Miami, Florida, United States, 33136 Germany Universitäts-Frauenklinik Göttingen, Germany Klinik für Frauenheilkunde und Geburtshilfe Regensburg, Germany Collapse <<

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参考文献

[1] Seitz S, Buchholz S, et al. Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125. BMC Cancer. 2014 Nov 19;14:847.
[2] Wang X, Krebs LJ, et al. A chemically labeled cytotoxic agent: two-photon fluorophore for optical tracking of cellular pathway in chemotherapy. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11081-4.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.5283 mL
- 2.6413 mL
- 5.2826 mL
- 5 mM
- 0.1057 mL
- 0.5283 mL
- 1.0565 mL
- 10 mM
- 0.0528 mL
- 0.2641 mL
- 0.5283 mL

技术信息

CAS号	139570-93-7	储存条件	粉末 2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C91H117N19O26	运输	蓝冰
分子量	1893.01	别名	Zoptarelin Doxorubicin;AN 152;AEZS-108

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01240629	Prostate Cancer ... more >> Hormone-resistant Prostate Cancer Recurrent Prostate Cancer Stage IV Prostate Cancer Collapse <<	Phase 1 Phase 2	Completed	-	United States, California ... more >> University of Southern California Los Angeles, California, United States, 90033-0804 Collapse <<
NCT01234519	Urothelial Carcinoma	Phase 1 Phase 2	Terminated(Poor recruitment)	-	United States, Florida ... more >> University of Miami Miller School of Medicine Miami, Florida, United States, 33136 United States, Pennsylvania Univerity of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT01698281	Breast Cancer	Phase 2	Terminated(Poor recruitment)	-	United States, Florida ... more >> University of Miami Miami, Florida, United States, 33136 Germany Universitäts-Frauenklinik Göttingen, Germany Klinik für Frauenheilkunde und Geburtshilfe Regensburg, Germany Collapse <<
NCT00569257	Ovarian Cancer ... more >> Endometrial Cancer Collapse <<	Phase 2	Completed	-	Bulgaria ... more >> University Hospital "Dr. Georgy Stranski" Pleven, Bulgaria, BG-5800 Regional Oncology Hospital Plovdiv Plovdiv, Bulgaria, BG-4002 Regional Oncodispensary "M.Markov" Varna, Bulgaria, BG-9010 Germany Klinik für Frauenheilkunde und Geburtshilfe, Charité Campus Virchow-Klinikum Berlin, Germany, D-13353 Frauenklinik, Klinikum Bremen-Mitte GmbH Bremen, Germany, D-28177 Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Germany, D-01307 Klinik für Frauenheilkunde, Universität Erlangen-Nürnberg Erlangen, Germany, D-91094 Universitätsfrauenklinik, Universitätsklinikum Essen, Germany, D-45122 Universitätsfrauenklinik, Klinikum der JWG Universität Frankfurt Frankfurt / Main, Germany, D-60591 Klinikum der Ernst-Moritz-Arndt-Universitaet, Klinik und Poliklinik fuer Gynaekologie und Geburtshilfe Greifswald, Germany, D-17487 Frauenklinik, Georg-August-Universität Göttingen Göttingen, Germany, D-37075 Frauenklinik, Medizinische Hochschule Hannover Hannover, Germany, D-30625 Frauenklinik, St. Vincentius Kliniken AG Karlsruhe, Germany, D-76135 Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Campus Kiel Kiel, Germany, D-24105 Frauenklinik, Klinikum Lüneburg Lüneburg, Germany, D-21339 Klinikum Suedstadt der Hansestadt Rostock, Universitaetsfrauenklinik und Poliklinik Rostock, Germany, D-18059 Klinik f. Gynäkologie u. Gyn. Onkologie, Dr. Horst Schmidt Kliniken GmbH Wiesbaden, Germany, D-65199 Collapse <<
NCT01767155	-	-	Completed	-	-
NCT01767155	Endometrial Cancer	Phase 3	Completed	-	-

Zoptarelin doxorubicin Catalog No. CSN20400

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