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CAS No.: 180288-69-1

Trastuzumab

Trastuzumab is a humanized IgG1 monoclonal antibody that binds to subdomain IV of HER2 receptor with high affinity and specifcity, inhibiting ligand-independent HER2 signalling and proteolytic cleavage of its extracellular domain.

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描述

Trastuzumab is a humanized IgG1 monoclonal antibody that binds to subdomain IV of HER2 receptor with high affinity and specifcity, inhibiting ligand-independent HER2 signalling and proteolytic cleavage of its extracellular domain. It was the frst HER2-targeted therapy approved for the treatment of HER2-positive breast cancer.

同义词

Herceptin

参考

Heo YA, Syed YY. Subcutaneous Trastuzumab: A Review in HER2-Positive Breast Cancer. Target Oncol. 2019;14(6):749-758. doi:10.1007/s11523-019-00684-y|https://pubmed.ncbi.nlm.nih.gov/31686307/

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