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AChR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN24514 | α-Conotoxin PnIA | 705300-84-1 | α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 = 9.56 nM) and α7 receptors (IC50 = 252 nM). |
CSN24532 | α-Conotoxin PIA | 669050-68-4 | α-Conotoxin PIA is a selective antagonist of α6-containing nAChRs with IC50 values of 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively. |
CSN24553 | α-Conotoxin MII | 175735-93-0 | α-Conotoxin MII is a potent and selective α3β2 and β3 nAChR antagonist. |
CSN24535 | α-Conotoxin AuIB | 216299-21-7 | α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. |
CSN24539 | Zamifenacin fumarate | 127308-98-9 | Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist with pKi value of 8.52. |
CSN51368 | VU0152099 | 612514-42-8 | VU0152100 is a potent and selective allosteric potentiator of M4 mAChR. |
CSN24545 | VU10010 | 633283-39-3 | VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptor. |
CSN24529 | VU 0238429 | 1160247-92-6 | VU 0238429 is a selective positive allosteric modulator of M5 receptors with EC50 values of 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively. |
CSN21894 | Vinconate | 70704-03-9 | Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor. |
CSN21914 | rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide hydrate | 411207-31-3 | Tiotropium Bromide is an considsered a long acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for COPD and asthma. |
CSN21862 | Timepidium bromide | 35035-05-3 | Timepidium bromide is an anticholinergic agent. |
CSN21851 | Tematropium | 113932-41-5 | Tematropium (CDDD3602) is a soft anticholinergics. |
CSN24523 | Telenzepine 2HCl | 147416-96-4 | Telenzepine 2HCl is a selective high affinity muscarinic M1 receptor antagonist with Ki of 0.94 nM. |
CSN26510 | Tebanicline 2HCl | 209326-19-2 | Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1]. |
CSN25667 | TC-2559 fumarate | 212332-35-9 | TC 2559 difumarate is a selective partial agonist of α4β2 receptors. The EC50 values are 0.18, 12.5, 14.0μM for α4β2, α4β4, α2β4 receptor subtypes respectively. |
CSN24554 | SEN12333 | 874450-44-9 | SEN 12333 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR) with EC50 and Ki of 1.6 μM, 260 nM in rat. It also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM). |
CSN21821 | Rapacuronium bromide | 156137-99-4 | Rapacuronium is an allosteric modulator of muscarinic acetylcholine receptor (mAChR). It is an aminosteroidal nondepolarizing neuromuscular blocking agent and used as a anesthesia. |
CSN26572 | PQCA | 1144504-35-7 | PQCA is a muscarinic M1 receptor positive allosteric modulator. PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. PQCA demonstrates robust efficacy in rodent and nonhuman primate (NHP) cognition assays. PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model. PQCA may be potential useful in finding new drugs for patients with Alzheimer's diseases |
CSN24541 | Perlapine | 1977-11-3 | Perlapine is a potent muscarinic DREADD agonist. |
CSN24528 | PD 102807 | 23062-91-1 | PD 102807 is a selective M4 muscarinic receptor antagonist with IC50 values of 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. |
CSN24547 | Oxotremorine sesquifumarate | 17360-35-9 | Oxotremorine sesquifumarate is a muscarinic agonist. |
CSN24548 | Oxotremorine M | 63939-65-1 | Oxotremorine M is a muscarinic agonist. |
CSN24538 | McN-A-343 | 55-45-8 | McN-A 343 is a selective muscarinic M1 receptor agonist. |
CSN24909 | (7R,7aR,14R,14aS)-Dodecahydro-2H,6H-7,14-methanodipyrido[1,2-a:1',2'-e][1,5]diazocine | 492-08-0 | Inhibition of human CYP2D6 expressed in Escherichia coli JM109 |
CSN26518 | Fesoterodine L-mandelate | 1206695-46-6 | Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB)[1][2]. |
CSN26519 | Fesoterodine | 286930-02-7 | Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB)[1][2]. |
CSN22004 | ENS-163 phosphate | 117707-51-4 | ENS-163 phosphate is a selective muscarinic M1 receptor agonist. |
CSN21625 | Elucaine | 25314-87-8 | Elucaine is an antagonist of muscarinic acetylcholine receptor with anti-ulcerative activity. |
CSN24537 | DMP-543 | 160588-45-4 | DMP 543 is a sitmulator of acetylcholine release. It can enhance K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM) and increase release of dopamine and glutamate (EC50 = 0.25 and 0.22 μM, respectively). |
CSN24518 | Dihydro-β-erythroidine HBr | 29734-68-7 | Dihydro-β-erythroidine hydrobromide is a nicotinic acetylcholine receptor antagonist of neuronal α4 receptor subunit, the IC50 values against α4β4 and α4β2 receptors are 0.19 and 0.37 μM, espectively. |
CSN24540 | DAU 5884 hydrochloride | 131780-48-8 | DAU 5884 HCl is a selective muscarinic M3 receptor antagonist. |
CSN21591 | Darenzepine | 84629-61-8 | Darenzepine is an inhibitor of muscarinic receptor. |
CSN24531 | Chlorisondamine diiodide | 96750-66-2 | Chlorisondamine diiodide is an exceptionally long lasting nicotinic antagonist with IC50 of ~ 1.6 mM. |
CSN24551 | Benzoquinonium chloride | 311-09-1 | Benzoquinonium dibromide is a nicotinic antagonist. |
CSN24542 | Arecaidine propargyl ester tosylate | 147202-94-6 | Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist. |
CSN24556 | AR-R17779 HCl | 178419-42-6 | AR-R 17779 hydrochloride is a selective alpha7 nicotinic agonist with Ki value of 190 nM for rat. |
CSN29468 | VQW-765 | 669770-29-0 | AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
CSN24525 | AQ-RA 741 | 123548-16-3 | AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). |
CSN22098 | Ambutonium bromide | 115-51-5 | Ambutonium bromide is an acetylcholine antagonist. |
CSN24526 | AF-DX 384 | 118290-26-9 | AF-DX 384 is a potent M2/M4 selective antagonist with pKi values of 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively. |
CSN24524 | Otenzepad | 102394-31-0 | AF-DX 116 is a selective M2 muscarinic receptor antagonist with Ki values of 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively. |
CSN24517 | Pozanicline 2HCl | 161416-61-1 | ABT 089 dihydrochloride is the high affinity and selective partial agonist of α4β2 with Ki of 16 nM. |
CSN24549 | Methylfurmethide iodide | 1197-60-0 | 5-Methylfurmethiodide is a potent muscarinic agonist. |
CSN24543 | 4-DAMP | 1952-15-4 | 4-DAMP is a muscarinic M3 antagonist. |
CSN24533 | 4-Acetyl-1,1-dimethylpiperazinium iodide | 75667-84-4 | 4-Acetyl-1,1-dimethylpiperazinium iodide is a nAChR agonist with Ki of 29.9 nM at α4β2. |
CSN24521 | 3-Bromocytisine | 207390-14-5 | 3-Bromocytisine is an agonist of α4β4, α4β2 and α7 nACh receptors with IC50s of 0.28, 0.30 and 31.6 nM respectively. |
CSN24552 | 1-(4-Methylpiperazin-1-yl)ethanone hydrochloride | 144205-68-5 | 1-Acetyl-4-methylpiperazine hydrochloride is a nAChR agonist. |
CSN24530 | (±)-Anatoxin A fumarate | 1219922-30-1 | (¡À)-Anatoxin A fumarat is a potent nicotinic agonist with Ki values of 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively. |
CSN24562 | (S)-(+)-Dimethindene maleate | 136152-65-3 | (S)-(+)-Dimethindene maleate is a subtype-selective M2 muscarinic receptor antagonist with pKi of 7.78 and is also a H1 histamine receptor antagonist with pKi of 7.48. |