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Sodium Channel
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17315 | XEN907 | 912656-34-9 | XEN907 is a spirooxindole NaV1.7 blocker, inhibits hNaV1.7 with IC50 of 3 nM. |
| CSN16795 | Tetracaine | 94-24-6 | Tetracaine can interfer the entry of sodium ions into nerve cells and used as a topical local anesthetic. |
| CSN16312 | Sodium Channel inhibitor 1 | 1198117-23-5 | Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a selective voltage-gated sodium channel for pain treatment. |
| CSN22177 | Sodium Channel inhibitor 2 | 653573-60-5 | Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c. |
| CSN23212 | Zoniporide dihydrochloride | 241799-10-0 | Selective NHE1 inhibitor |
| CSN12526 | Ropivacaine HCl monohydrate | 132112-35-7 | Ropivacaine HCl, a local anaesthetic, can reversibly inhibit sodium ion influx and block impulse propagation along nerve fibres. |
| CSN24189 | Rimeporide | 187870-78-6 | Rimeporide is a potent and selective NHE1 inhibitor. |
| CSN12584 | 6-(Trifluoromethoxy)benzo[d]thiazol-2-amine | 1744-22-5 | Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis. |
| CSN18778 | 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride | 5875-06-9 | Proparacaine HCl is an antagonist of voltage-gated sodium channels with ED50 of 3.4 mM. |
| CSN13879 | 4-Amino-N-(2-(diethylamino)ethyl)benzamide hydrochloride | 614-39-1 | Procainamide HCl is a blocker of sodium channel and an inhibitor of DNA methyltransferase. It is an anti-arrhythmic agent. |
| CSN16780 | Prilocaine | 721-50-6 | Prilocaine is a local anesthetic of the amino amide type. |
| CSN16772 | Phenytoin sodium | 630-93-3 | Phenytoin sodium is a stabilizer of inactive voltage-gated sodium channel. |
| CSN12795 | 5,5-Diphenylhydantoin | 57-41-0 | Phenytoin is an inactive voltage-gated sodium channel stabilizer. |
| CSN21395 | PF-06869206 | 2227425-05-8 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| CSN13891 | PF 05089771 | 1235403-62-9 | PF-05089771 is a Nav1.7 channel blocker with an IC50 of 8.6 nM. |
| CSN22144 | PF 04531083 | 1079400-07-9 | PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain |
| CSN16737 | Oxcarbazepine | 28721-07-5 | Oxcarbazepine is a voltage-gated sodium channel blocker with IC50 of 160 μM and it is used for the treatment of partial seizure. |
| CSN17076 | Nicainoprol | 76252-06-7 | Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent. |
| CSN21275 | NHE3-IN-1 | 632355-68-1 | NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1. |
| CSN17697 | Nav1.7-IN-2 | 1332295-35-8 | Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. |
| CSN16914 | Nav1.7 inhibitor | 1355631-24-1 | Nav1.7 inhibitor is a sulfonamide derivative with potent Nav1.7 inhibition activity. |
| CSN16180 | Mepivacaine HCl | 1722-62-9 | Mepivacaine, a tertiary amine, is used as a local anesthetic. |
| CSN16268 | Levobupivacaine HCl | 27262-48-2 | Levobupivacaine HCl is a local anaesthetic compound belonging to the amino amide group and a long-acting local anesthetic. |
| CSN18204 | ICA-121431 | 313254-51-2 | ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition on human, monkey and dog Nav1.7. |
| CSN16320 | GS967 | 1262618-39-2 | GS-967 is a selective inhibitor of cardiac late sodium current (late INa ). The IC50 values in ventricular myocytes and isolated hearts are 0.13 μM and 0.21 μM. |
| CSN24781 | GNE-131 | 1629063-81-5 | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
| CSN19828 | Funapide | 1259933-16-8 | Funapide is an analgesic agent which may be useful for the treatment of a variety of chronic pain conditions. |
| CSN21301 | FR183998 | 239440-20-1 | FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
| CSN20530 | Eniporide | 176644-21-6 | Eniporide is an inhibitor of Na+/H+ exchange that prevents ischemic Na+ overload. |
| CSN19026 | Eleclazine HCl | 1448754-43-5 | Eleclazine HCl is a late Na+ current inhibitor with IC50 value of 0.7 μM. |
| CSN21438 | Disopyramide | 3737-09-5 | Disopyramide can block sodium channel, it is a class IA antiarrhythmic drug. |
| CSN13878 | Raxatrigine | 934240-30-9 | CNV1014802 is a blocker of Nav1.7 sodium channel. |
| CSN15719 | Raxatrigine HCl | 934240-31-0 | CNV1014802 HCl is a blocker of Nav1.7 sodium channel with analgesic effects. |
| CSN16789 | Dibucaine | 85-79-0 | Cinchocaine is amide type local anesthetic that is generally used for surface anesthesia. |
| CSN20559 | Cariporide | 159138-80-4 | Cariporide is a selective inhibitor of Na+/H+ exchanger isoform 1 (NHE1) with IC50 value of 0.05 μM with cardioprotective and antiarrhythmic effects. |
| CSN16283 | 5H-Dibenzo[b,f]azepine-5-carboxamide | 298-46-4 | Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug. |
| CSN16147 | 1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide | 38396-39-3 | Bupivacaine, an amide local anesthetic, reversibly binds to specific sodium ion channels that decreases the stabilization of membrane . |
| CSN12547 | Bupivacaine HCl | 18010-40-7 | Bupivacaine HCl is a local anaesthetic drug belonging to the amino amide group. |
| CSN22716 | BI-9627 | 1204329-34-9 | BIX NHE1 Inhibitor is a potent and selective NHE1 inhibitor with IC50 of 31 nM. |
| CSN16674 | Ethyl 4-aminobenzoate | 94-09-7 | Benzocaine, the ethyl ester of p-aminobenzoic acid (PABA), inhibits voltage-dependent sodium channels (VDSCs) on the neuron membrane and used as a local anesthetic. |
| CSN18717 | Ethyl 4-aminobenzoate hydrochloride | 23239-88-5 | Benzocaine HCl is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| CSN23800 | Benzamil HCl | 161804-20-2 | Benzamil hydrochloride is a specific blocker of sodium channel (ENaC). |
| CSN20028 | AMG8379 | 1642112-31-9 | AMG8379 is a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV1.7. |
| CSN18871 | AM-0466 | 1642113-59-4 | AM-0466 shows robust pharmacodynamic activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect in open field activity. |
| CSN16066 | A-803467 | 944261-79-4 | A 803467 selectively block Nav1.8 sodium channel with IC50 of 8 nM. |
| CSN12884 | (-)-Sparteine sulfate pentahydrate | 6160-12-9 | (-)-Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. |
| CSN16841 | (7S,7aR,14S,14aS)-Tetradecahydro-7,14-methanodipyrido[1,2-a:1',2'-e][1,5]diazocine | 90-39-1 | (-)-Sparteine is a class 1a antiarrhythmic agent and a sodium channel blocker. |
| CSN12547 | Bupivacaine hydrochloride | 18010-40-7 | |
| CSN52433 | (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol sulfate hydrate(2:1:2) | 6591-63-5 |
