优势价格
快速发货
品质保证
技术支持
400-920-2911 sales@csnpharm.cn
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18839 | Quisinostat 2HCl | 875320-31-3 | Quisinostat 2HCl is a second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11, greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. |
| CSN18808 | Eganelisib | 1693758-51-8 | IPI-549 is a selective phosphoinositide-3-kinase (PI3K)-γ inhibitor with IC50 of 16 nM as an immuno-oncology clinical candidate. |
| CSN18810 | GSK2256098 | 1224887-10-8 | GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
| CSN18822 | Mivebresib | 1445993-26-9 | Mivebresib, also known as ABBV-075, is an inhibitor of bormodomain and extra terminal domain (BET). The Ki values of BRD2, BRD4, BRDT are 1 nM - 2.2 nM. |
| CSN18841 | N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide | 1702259-66-2 | H3B-6527 acts as a selective FGFR4 inhibitor (IC50 <1.2 nM) over FGFR1-3. |
| CSN18854 | EED226 | 2083627-02-3 | EED226 is a potent and selective PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED. |
| CSN18894 | MX69 | 1005264-47-0 | MX69 is a dual inhibitor of MDM2 and XIAP which can induce MDM2 downregulation resulted not only in inhibition of XIAP expression, but also in activation of p53. |
| CSN18918 | NSC632839 | 157654-67-6 | NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively). |
| CSN18830 | Fevipiprant | 872365-14-5 | Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. |
| CSN18825 | IMR-1 | 310456-65-6 | IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex with IC50 of 6 μM for targeting the transcriptional activation. |
| CSN18807 | Nutlin-3 | 548472-68-0 | Nutlin 3 is an MDM2 antagonist which can activate p53 pathway through inhibition of p53-MDM2 interaction. |
| CSN18840 | MKC3946 | 1093119-54-0 | MKC3946 is a small-molecule IRE1α endoribonuclease domain inhibitor which can block XBP1 splicing. |
| CSN18844 | ML348 | 899713-86-1 | ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases. |
| CSN18805 | Epothilone A | 152044-53-6 | Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM. |
| CSN18802 | (S,S)-TAPI-1 | 171235-71-5 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
| CSN18811 | PIK-293 | 900185-01-5 | PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. |
| CSN18803 | Olverembatinib dimesylate | 1421783-64-3 | GZD824 dimesylate is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. |
| CSN18843 | UNC3866 | 1872382-47-2 | UNC3866 is a high-affinity CBX4 and CBX7 inhibitor with Ki values of 94 and 97 nM, respectively. |
| CSN18848 | RAF709 | 1628838-42-5 | RAF709 is an inhibitor of c-Raf and b-Raf with IC50 of 0.5 nM and 1.8 nM, respectively. |
| CSN18824 | AZD0156 | 1821428-35-6 | AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. |
| CSN18900 | (E)-[6]-Dehydroparadol | 878006-06-5 | (E)-[6]-Dehydroparadol, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively. |
| CSN18826 | IMR-1A | 331862-41-0 | IMR-1A is the metabolite of IMR-1, a Notch inhibitor targeting the transcriptional activation. |
| CSN18898 | WEHI-539 HCl | 2070018-33-4 | WEHI-539 HCl is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. |
| CSN18880 | MMAF-OMe | 863971-12-4 | MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. |
| CSN18919 | Acelarin | 840506-29-8 | Acelarin is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
| CSN18872 | Asciminib | 1492952-76-7 | Asciminib is a potent and selective allosteric Bcr-Abl inhibitor and inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. |
| CSN18851 | NSC23005 Sodium | 1796596-46-7 | NSC 23005 Sodium is an effective p18 inhibitor with ED50 of 5.21 nM in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. |
| CSN18897 | Pyridoclax | 1651890-44-6 | Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM. |
| CSN18920 | ML364 | 1991986-30-1 | ML364 is an USP2 inhibitor. |
| CSN18842 | BMS-986020 | 1257213-50-5 | BMS-986020 is an LPA1 antagonist. |
| CSN18809 | LY3177833 | 1627696-51-8 | LY3177833 is an CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. |
| CSN18916 | AUZ 454 | 853299-07-7 | K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2 (WT), CDK2 (C118L), CDK2 (A144C), and CDK2 (C118L/A144C), respectlvely. |
| CSN18817 | BAY1125976 | 1402608-02-9 | BAY1125976 is a selective allosteric AKT1/2 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. |
| CSN18847 | XMD16-5 | 1345098-78-3 | XMD16-5 is an inhibitor of TNK2 with IC50 value of 0.38µM, potently inhibiting phosphorylation of TNK2 truncation mutations found in solid tumor types. |
| CSN18829 | CCT245737 | 1489389-18-5 | CCT245737 is a potent, ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM. |
| CSN18818 | Tomivosertib | 1849590-01-7 | eFT508 is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM. |
| CSN18873 | Gambogenic acid | 173932-75-7 | Gambogenic acid binds to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70‐interacting protein (CHIP)‐mediated ubiquitination. |
| CSN18882 | Cys-mcMMAD | N/A | Cys-mcMMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. |
| CSN18874 | GNA002 | 1385035-79-9 | GNA002 binds to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70‐interacting protein (CHIP)‐mediated ubiquitination. |
| CSN18858 | CHMFL-EGFR-202 | 2089381-40-6 | CHMFL-EGFR-202 can form a covalent bond with Cys797 in a distinct "DFG-in-C-Helix-out" inactive EGFR conformation. |
| CSN18859 | TMP195 | 1314891-22-9 | TMP195 is an inhibitor of class IIa histone deacetylase (HDAC) with IC50 of 15 nM - 59 nM for HDAC4, 5, 7 and 9. |
| CSN18899 | 2-(4-((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)-1-morpholinoethanone dihydrochloride | 2070009-27-5 | p53 and MDM2 proteins-interaction-inhibitor 2HCl is an inhibitor of the interaction between p53 and MDM2 proteins. |
| CSN18917 | 6-Chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one | 1997370-71-4 | SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling. |
| CSN18861 | AZ1366 | 1645286-58-3 | AZ1366 inhibits tankyrase as a cotreatment strategy with EGFR inhibition in an identifiable subset of EGFR-driven NSCLC. |
| CSN18870 | CHMFL-BTK-01 | 2095280-64-9 | CHMFL-BTK-01 is an irreversible BTK inhibitor targeting Cys481 residue while completely abolishing BMX, JAK3 and EGFR's activity. |
| CSN18846 | XMD8-87 | 1234480-46-6 | XMD8-87 is a tyrosine kinase nonreceptor 2 (TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations. |
| CSN18881 | Taltobulin hydrochloride | N/A | Taltobulin HCl is an cytotoxin, an analogue of hemiasterlin, and a potent tubulin inhibitor. |
