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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19462 | (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
| CSN19480 | Ginsenoside Rf | 52286-58-5 | Ginsenoside Rf, extracted from the traditional Chinese herb ginseng, is a natural anticancer products known for its favorable safety and efficacy profiles. |
| CSN19501 | Ginsenoside Rc | 11021-14-0 | Ginsenoside Rc is a steroid glycoside, and a triterpene saponin found exclusively in the plant genus Panax (ginseng) with properties that inhibit or prevent tumors growth. |
| CSN19502 | Ginsenoside Rb3 | 68406-26-8 | Ginsenoside Rb3 is a natural triterpenoid saponin with various pharmacological effects. |
| CSN19253 | (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | 362-07-2 | 2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration. |
| CSN19269 | Bafetinib | 859212-16-1 | Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. |
| CSN19473 | 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid | 153559-49-0 | Bexarotene is a selective agonist of RXRβ (IC50 = 24 nM), RXRγ (IC50 = 25 nM) and RXRα (IC50 = 33 nM) with antineoplastic activity. |
| CSN19264 | N-(3-((5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide dihydrochloride | 2095433-94-4 | THZ1 2HCl is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain. THZ1 2HCl also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM). |
| CSN19330 | (41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one | 519-02-8 | (+)-Matrine is a naturally occuring κ-opioid and μ-opioid receptor agonist. |
| CSN19334 | MNS | 1485-00-3 | MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. It acts by inhibiting NLRP3 ATPase activity and binding to the NACHT and LRR domains. |
| CSN19363 | (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 86639-52-3 | SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| CSN19369 | 4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 147-94-4 | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. |
| CSN19389 | 3-Methyl-3H-purin-6-amine | 5142-23-4 | 3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM. |
| CSN19418 | (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | 302-79-4 | Retinoic acid is a ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR) that can prime embryonic stem cells to become neurons and induce granulocytic differentiation. |
| CSN19419 | (1α,6β,7α,14R)-1,5,6,14-Tetrahydroxy-4,4-dimethyl-8-methylenedecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-one | 28957-04-2 | Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens. Oridonin interacts with the cysteine 279 of NLRP3 NACHT domain through a covalent bond, abolishes NLRP3-NEK7 interaction, and inhibits consequent activation of NLRP3 inflammasome. |
| CSN19420 | (S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one | 5508-58-7 | Andrographolide is a naturally occuring NF-κB inhibitor. |
| CSN19438 | 4,5,6,7-Tetrabromo-1H-benzo[d][1,2,3]triazole | 17374-26-4 | TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
| CSN19463 | (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride | 100286-90-6 | Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
| CSN19493 | Dovitinib | 405169-16-6 | Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM. |
| CSN19496 | 5-Fluoropyrimidine-2,4(1H,3H)-dione | 51-21-8 | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| CSN19504 | Zoledronic Acid | 118072-93-8 | Zoledronic acid, a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. |
| CSN19518 | 4-Hydroxybenzoic acid | 99-96-7 | 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties. |
| CSN19519 | all-trans-N-(4-Hydroxyphenyl)retinamide | 65646-68-6 | Fenretinide, the deriverative of retinoid, can bind to retinoic acid receptors (RAR) and induce cell death. |
| CSN19392 | 3,3'-Diindolylmethane | 1968-05-4 | 3,3'-Diindolylmethane is an AR structurally similar androgen receptor antagonist. |
| CSN19245 | SKL2001 | 909089-13-0 | SKL2001 is Wnt/β-catenin pathway agonist which interferes in the interaction of Axin/β-catenin. |
| CSN19485 | Dioscin | 19057-60-4 | Dioscin, a natural product isolated and purified from the rhizome of Dioscorea Zingiberensis C.H.Wright, is a potent ITGA5 inhibitor, showing potent anti-cancer effect against a variety of tumor cell lines. |
| CSN19250 | 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine hydrochloride | 1313883-00-9 | ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form. |
| CSN19256 | Ossirene | 106566-58-9 | AS101 is a potent Caspase-1 inhibitor which can inhibit IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release through Caspase, performing as an immunomodulator. |
| CSN19507 | SB-366791 | 472981-92-3 | SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5.7±1.2 nM. |
| CSN19261 | Endoxifen HCl | 1197194-41-4 | Endoxifen HCl, the active metabolite of Tamoxifen, is a potent antiestrogen that targets estrogen receptor. |
| CSN19688 | BAY-1436032 | 1803274-65-8 | BAY 1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). |
| CSN19674 | GNE-272 | 1936428-93-1 | GNE-272 is a potent and selective in Vivo Probe for the Bromodomains of CBP/EP300 (CBP IC50 = 0.02 μM, EP300 IC50 = 0.03 μM, BRET IC50 = 0.41 μM, BRD4(1) C50 = 13 μM). |
| CSN19268 | NSC 23766 | 733767-34-5 | NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM and does not inhibit the closely related targets, Cdc42 or RhoA. |
| CSN19671 | MI-538 | 1857417-10-7 | MI-538 is a potent and selective MLL inhibitor (mixed lineage leukemia inhibitor). |
| CSN19370 | C75 | 218137-86-1 | C75 is a potent fatty-acid synthase (FASN) inhibitor with IC50 of 35.4 μM (LNCaP cell Proliferation inhibition). |
| CSN19254 | Alrizomadlin | 1818393-16-6 | APG-115 is a compound with a very high affinity to MDM2 (Ki < 1 nM), potent cellular activity, and an excellent oral pharmacokinetic profile. |
| CSN19670 | N-((R)-Cyclopropyl(pyridin-2-yl)methyl)-3-(4-((3-endo)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide | 1430741-35-7 | CFI-401870 is an orally bioavailable, potent tyrosine threonine kinase (TTK) inhibitor (TTK IC50 < 10 nM, HCT116 GI50 < 0.1 μM). |
| CSN19288 | Stafib-1 | 1688703-26-5 | Stafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner. |
| CSN19446 | Penfluridol | 26864-56-2 | Penfluridol, a T-type calcium channel blocker, is a highly potent, first generation diphenylbutylpiperidine antipsychotic. |
| CSN19355 | AKBA | 67416-61-9 | AKBA is a novel Nrf2 activator which can increase basal and UVA-induced levels of Nrf2. |
| CSN19258 | Mavelertinib | 1776112-90-3 | PF-06747775 provides potent EGFR activity against the four common mutants (exon 19 deletion (Del), L858R, and double mutants T790M/L858R and T790M/Del), selectivity over wild-type EGFR, and desirable ADME properties. |
| CSN19270 | AZD9291 Dimesylate | N/A | Osimertinib Dimesylate is a potent and selective mutated forms EGFR inhibitor (Exon 19 deletion EGFR IC50 =12.92 nM, L858R/T790M EGFR IC50 = 11.44 nM, wild type EGFR IC50 = 493.8 nM). |
| CSN19263 | EPZ011989 hydrochloride | 2095432-26-9 | EPZ011989 HCl is a potent, selective, orally bioavailable EZH2 inhibitor with Ki of < 3 nM. |
| CSN19281 | MB-7133 | 685111-92-6 | MB07133 is a cytarabine (araC) prodrug that uses the HepDirect technology to target production of the active form of araC, araC triphosphate (araCTP), to the liver. |
| CSN19672 | MSC2530818 | 1883423-59-3 | MSC2530818 is a Potent, Selective, and Orally Bioavailable CDK8 inhibitor with CDK8 IC50 = 2.6 nM. |
| CSN19679 | MMP13-IN-2 | 935759-55-0 | MMP13-In-1 is a selective Matrix Metalloproteinase (MMP)-13 inhibitors. |
