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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21898 | 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline | 288383-20-0 | Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively. |
| CSN22142 | CD 437 | 125316-60-1 | CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist. |
| CSN22108 | CHK1 inhibitor | 2097938-64-0 | GDC-0575 is a potent and selective CHK1 inhibitor. |
| CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |
| CSN22365 | CC-90003 | 1621999-82-3 | CC-90003 is an irreversible inhibitor of ERK 1/2 with antitumor activity. |
| CSN22124 | WAY 163909 | 428868-32-0 | WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with Ki of 10.5±1.1 nM, respectively. |
| CSN22200 | N33-TEG-COOH | 201467-81-4 | N33-TEG-COOH is a linker used to link the warhead and the E3 ligase ligand. |
| CSN22133 | W146 | 909725-61-7 | W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. |
| CSN22212 | EZM 2302 | 1628830-21-6 | EZM 2302 is the first potent and selective inhibitor of CARM1 enzymatic activity with IC50 value of 6 nM. |
| CSN22128 | FTI 276 | 170006-72-1 | FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human. |
| CSN22171 | (2R,3S,4R,5S,6S)-3-Fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triol | 74554-11-3 | SGN-2FF is an oral inhibitor of fucosylation, directly inhibits fucosyltransferase activity, and possesses antitumor activity. |
| CSN22222 | BAY-320 | 1445830-50-1 | BAY-320 is a Bub1 inhibitor, with an IC50 of 680 nM for human Bub1 in the presence of 2 mM ATP. |
| CSN22125 | AZ-23 | 915720-21-7 | AZ-23 is a potent, orally bioavailable Trk kinase inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. |
| CSN22120 | LG-100064 | 153559-46-7 | LG-100064 is an agonist of RXRα, RXRβ and RXRγ with EC50s of 330 nM, 200 nM, and 260 nM, respectively. |
| CSN22145 | Itacitinib adipate | 1334302-63-4 | Itacitinib adipate is a selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis. |
| CSN22147 | Zanubrutinib | 1691249-45-2 | Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor. |
| CSN22105 | (Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol | 68047-06-3 | 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. |
| CSN22109 | Ripretinib | 1442472-39-0 | DCC-2618 is a pan-KIT and PDGFRA inhibitor, and has antitumor activity. |
| CSN22189 | NMDI14 | 307519-88-6 | NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. |
| CSN22161 | Balamapimod | 863029-99-6 | MKI 833 is a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway. |
| CSN21414 | Transcrocetin meglumine salt | N/A | Transcrocetin meglumine salt, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. |
| CSN22174 | CE-245677 | 717899-97-3 | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
| CSN22193 | BI-3812 | 2166387-64-8 | BI-3812 is a BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM. |
| CSN22164 | Regorafénib N-oxyde (M2) | 835621-11-9 | Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. |
| CSN22155 | Amphethinile | 91531-98-5 | Amphethinile is an anti-tubulin agent and a novel anti-mitotic agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM. |
| CSN22194 | TC13172 | 2093393-05-4 | TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2±0.6 nM for HT-29 cells. |
| CSN22195 | PROTAC BET Degrader 9 | 2093386-22-0 | PROTAC BET degrader-9 is PROTAC targeting on BET proteins, consist of a BET inhibitor HJB97 as the warhead ligand and Pomalidomide as CRBN ligand. |
| CSN22196 | Golidocitinib | 2091134-68-6 | AZD-4205 is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2, and shows little inhibition on JAK3 (IC50, >14.7, >30 μM, respectively). |
| CSN22202 | PQR530 | 1927857-61-1 | PQR530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. |
| CSN22221 | BAY-826 | 1448316-08-2 | BAY-826 is a selective and potent TIE-2 inhibitor with Kdof 1.6 nM, respectively. |
| CSN22232 | Pimitespib | 1260533-36-5 | TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively. |
| CSN22203 | HAT-IN-1 | 1889281-94-0 | HAT-IN-1 is an inhibitor of HAT, used in the research of cancer. |
| CSN22243 | SNT-207858 | 1104080-42-3 | SNT-207858 is a non-peptide, orally active melanocortin MC-4 receptor antagonist penetrating the blood brain barrier. |
| CSN22225 | NecroX-5 | 1383718-29-3 | NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. |
| CSN22227 | Vactosertib HCl | 1352610-25-3 | EW-7197 HCl is a small-molecule ATP-competitive inhibitor of TGFβRI (ALK5) with an IC50 of 12.9 nM. |
| CSN22247 | R916562 | 1037798-41-6 | R916562 is a potential and selective Axl/VEGF-R2 dual inhibitor with IC50s of 136 and 24 nM, respectively. |
| CSN22228 | FT-1518 | 1313026-58-2 | FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. |
| CSN22248 | CC-885 | 1010100-07-8 | CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. |
| CSN22229 | BACE1-IN-1 | 1310347-50-2 | BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. |
| CSN22209 | DDR Inhibitor | 1644069-80-6 | DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM. |
| CSN22351 | Arzoxifene HCl | 182133-27-3 | Arzoxifene hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. |
| CSN22341 | Pelitrexol | 446022-33-9 | AG 2037 (Pelitrexol) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT). |
| CSN22352 | ATM-3507 | 1861449-70-8 | ATM-3507 is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. |
| CSN22342 | AGI-24512 | 2201066-53-5 | AGI-24512 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-24512 blocks growth of MTAP-deleted cancer cells in vitro. |
| CSN22364 | CB-1158 HCl | N/A | CB-1158 HCl is a potent and orally bioavailable inhibitor of arginase, with IC50s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively. |
| CSN22343 | 2,3-Diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | 2201066-35-3 | AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. |
| CSN22366 | CDK8/19-IN-1 | 1818427-07-4 | CDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively. |
| CSN22367 | CDK8-IN-3 | 1884500-15-5 | CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. |
| CSN22335 | Acolbifene | 182167-02-8 | Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM. |
| CSN22358 | BI-3802 | 2166387-65-9 | BI-3802 is a highly potent BCL6 degrader, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3802 has antitumor activity. |
