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Flavonoids

Flavonoids

货号 产品名 CAS号 信息
CSN16440 Wogonin 632-85-9 Wogonin acts as an inhibitor of COX2 with IC50 of 46 μM without affecting COX-1 and inhibits the NF-κB pathway-mediated iNOs induction. Wogonin can be isolated from the root of scutellaria baicalensis georgi.
CSN14293 Warangalone 4449-55-2 Warangalone is a powerful inhibitor of protein kinase A isolated and purfied from the stem bark of Erythrina addisoniae, shows marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.
CSN19902 Vitexicarpin 479-91-4 Vitexicarpin, a natural product isolated and purified from the fruits of Vitex trifolia L. var. simplicifolia Cham., can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells, and may become a potential leading drug in the therapy of prostate carcinoma.
CSN19352 2-(3,4-Bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 7085-55-4 Troxerutin, also known as vitamin P4, can inhibit platelet aggregation and the production of ROS. It is a flavonol isolated from Sophora japonica and used as a vasoprotective.
CSN14606 Thevetiaflavone 29376-68-9 Thevetiaflavone is a natural product isolated and purified from the herbs of Wikstroemia indica.
CSN14278 Tetrahydroamentoflavone 48236-96-0 Tetrahydroamentoflavone, a potent XO inhibitor isolated and purified from the herbs of Selaginella uncinata, exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, and has anti-inflammatory effects. It shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 mg/mL (COX-2)).
CSN16637 Tectoridin 611-40-5 Tectoridin, an isoflavone, is a natural product isolated and purified from the rhizomes of belamcanda chinensis (L.) DC. with anti-inflammatory activities.
CSN14818 Steppogenin 56486-94-3 Steppogenin is a natural prodcut isolated and purified from the stems of Cudrania tricuspidata with cytotoxicity and significant tyrosinase inhibition activity.
CSN14314 Sideritoflavone 70360-12-2 Sideritoflavone is a natural product isolated and purified from the aerial parts of Stachys glutinosa. with anti-inflammatory effect , and is a selective inhibitor of lipoxygenase activity in vitro.
CSN19422 7-Hydroxy-3-(4-hydroxyphenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one 3681-99-0 Puerarin, an isoflavones, is antagonist of 5-HT2C receptor and benzodiazepine site that can reduce anxiety symptoms associated with alcohol withdrawal. Puerarin is found in the root of radix puerariae.
CSN19444 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 552-59-0 Prunetin can inhibit the aldehyde dehydrogenases in liver. It is a flavonoid compound isolated from the herbs of millettia dielsiana.
CSN14282 Podocarpusflavone A 22136-74-9 Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus, and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
CSN14296 Pedalitin 22384-63-0 Pedalitin is a natural mixed-type inhibitor of tyrosinase isolated and purified from the herbs of Rabdosia rubescens, and is also a competitive inhibitor of α-glucosidase.
CSN14602 Mulberrin 62949-79-5 Mulberrin can act as HIV-1 reverse transcriptase inhibitor and reduce blood sugar of type II diabetes in rats. It is purified from the root bark of morus alba L.
CSN15664 2-(2,4-Dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-en-1-yl)pyrano[2,3-f]chromen-4(8H)-one 62596-29-6 Morusin shows suppression of NFκB and STAT3 in many cancer cell lines including HT-29, A549, MCF-7, and MDA-MB-231. It is a flavonoid purified from the root bark of morus alba L. with antitumor activity.
CSN18660 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one 491-70-3 Luteolin is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Kis of 15.0/6.4/13.9/11.1/9.5 μM, respectively, it is a flavonoid found in Terminalia chebula.
CSN14311 Licorisoflavan A 129314-37-0 Licorisoflavan A and licoricidin have potential for the development of host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.
CSN15416 Leachianone G 152464-78-3 Leachianone G, a natural product isolated and purified from the roots of Sophora flavescens Ait., shows inhibitory activities against pancreatic lipase, and may be used as drug candidate to control obesity. Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, and shows potent antiviral activity (IC(50) = 1.6 mg/mL).
CSN14312 Ladanein 10176-71-3 Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.
CSN15422 Kushenol X 254886-77-6 Kushenol X is a natural product isolated and purified from the roots of Sophora flavescens Ait. exhibiting inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
CSN14297 Kushenol A 99217-63-7 Kushenol A, a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors isolated and purified from the roots of Sophora flavescens Ait., exhibits inhibitory activity against sodium-dependent glucose cotransporter 2(SGLT2 and shows selective alpha-glucosidase inhibitory activity.
CSN16382 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one 520-18-3 Kaempferol acts as an inverse agonist that directly binds ERRα and ERRγ. It is a natural flavonol with antitumor activity.
CSN19903 Isoorientin 4261-42-1 Isoorientin is a natural product isolated and purified from the herbs of Polygonum orientale Linn. with antioxidant activity.
CSN19464 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 489-32-7 Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold selective for PDE5 than PDE4 and exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. It is a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum..
CSN19421 5-Hydroxy-3-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 529-59-9 Genistin is a isoflavone which has a role in blocking cell cycle and inducing apoptosis. It is also a modulator of estrogen receptor. Genistin can be isolated from the seeds of glycine max (L.) merr. and used as negative control of genistein.
CSN18651 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 446-72-0 Genistein has multiple biological functions. It can inhibit several tyrosine kinases (IC50 of 0.6 μM for EGFR), inhibits DNA topoisomerase-II and activation of PPARs. Genistein is a phytoestrogen which has selective estrogen receptor modulator properties.
CSN14824 Derrone 76166-59-1 Derrone, a natural product isolated and purified from the herbs of Cudrania tricuspidata, may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens, and is an Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.
CSN15117 Dehydroglyasperin C 199331-35-6 Dehydroglyasperin C, a natural product isolated and purified from the roots of Glycyrrhiza uralensis Fisch, suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.
CSN17329 7-Hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 486-66-8 Daidzein can act as an inhibitor of tyrosine kinase and an activator of estrogen receptor. It is inactive analogue of genistein.
CSN15420 Corylifol C 775351-91-2 Corylifol C is a natural product isolated and purified from the seeds of Psoralea corylifolia L., and a potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor (EGFR): 1.1 and 4.4 × 10(-6) μg/mL, respectively).
CSN14607 Corylifol A 775351-88-7 Corylifol A is a phenolic compounds isolated from Psoralea corylifolia and inhibits IL-6-induced STAT3 activation and phosphorylation (IC50=0.8 μM).
CSN15663 Bavachin 19879-32-4 Bavachin, a flavonoid phytoestrogen, can activate the estrogen receptors ERα (EC50 = 320 nM) and ERβ (EC50 = 680 nM).
CSN15665 5,7-Dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 113558-15-9 Baohuoside I, a flavonoid, acts as an apoptosis inducer and a down-regulator of durvivin and cyclin D1 expression. It is used as an anti-cancer agent and can be isolated and purified from the roots of epimedium brevicornu Maxim.
CSN16193 5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-Glucopyranosiduronic Acid 21967-41-9 Baicalin, the glucuronide of baicalein, exhibits the reduction of the expression of NF-κB and effect on GABA receptor. Baicalin can be extracted from the root of astragalus membranaceus with antioxidant and anti-inflammatory activities.
CSN15955 (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one 29838-67-3 Astilbin is a flavonoid compound that can enhance NRF2 activition with anti-inflammatory properties. It could be extracted from chinese astilbe. Astilbin has been found to have significant immunosuppressive effects in recent years.
CSN16319 Alpinetin 36052-37-6 Alpinetin can act as an inhibitor of UCK2 and shows antioxidant, anticancer and antithrombotic properties. Alpinetin is mainly found in ginger plants.
CSN15031 Agrimonolide 6-O-β-D-glucoside 126223-29-8 Agrimonolide-6-O-glucopyranoside has antimicrobial activity.
CSN19459 7,4'-Di-O-methylapigenin 5128-44-9 7,4'-Di-O-methylapigenin, a flavonoid purified from aquilaria sinensis, can inhibit α-glucosidase, α-amylase enzymes and enhance 2-NBDG uptake in L6 cells. It has hypolipidemic effect.
CSN19324 3-O-Methylquercetin 1486-70-0 3-O-Methylquercetin, a natural product isolated and purified from the herbs of Croton cascarilloides with antiviral, anti-inflammatory and bronchodilating effects, is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value. 3-O-Methylquercetin also inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.
CSN16835 (2R,3R)-2-(3,4,5-Trihydroxyphenyl)chromane-3,5,7-triol 970-74-1 (-)-Epigallocatechin is a plant secondary metabolite abundant in green tea, it can prevent conversion of unfolded native polypeptides to amyloid fibrils.
CSN16836 (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate 989-51-5 (-)-Epigallocatechin Gallate, an antioxidant, inhibits telomerase and DNA methyltransferase. It is a polyphenol flavonoid extracted from green tea.
CSN16833 (-)-Catechin gallate 130405-40-2 (-)-Catechin gallate is a natural product isolated and purified from the wood of Acacia catechu (L.F.) Willd., can enhance Fe(2+)-induced lipid peroxidation.
CSN15641 (+)-Gallocatechin 970-73-0 (+)-Gallocatechin, a natural product isolated and purified from the wood of Acacia catechu (L.F.) Willd., has moderate affinity to the human cannabinoid receptor.
CSN16512 (+)-Catechin 154-23-4 (+)-Catechin, a plant secondary metabolite, is an antioxidant flavonoid found in the bark of taxus yunnanensis with anti-atherosclerosis.
CSN16846 (2R,3S)-2-(3,4-Dihydroxyphenyl)chromane-3,5,7-triol xhydrate 225937-10-0 (+)-Catechin, a natural product isolated and purified from the herbs of Camellia sinensis, has antioxidant activity and is effective in reducing oxidative stress.
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