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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21246 | YM-53601 free base | 182959-28-0 | YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents. |
| CSN21268 | SB-568849 | 395679-53-5 | SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7. |
| CSN21267 | YM348 | 372163-84-3 | YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM). |
| CSN21257 | FR194738 free base | 204067-45-8 | FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. |
| CSN21311 | RP 73163 Racemate | 136609-53-5 | RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity. |
| CSN22131 | Cort108297 | 1018679-79-2 | Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM. |
| CSN22389 | E-5324 | 141799-76-0 | E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM. |
| CSN22112 | Declaben | 111149-90-7 | Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively. |
| CSN22439 | JTT 551 | 776309-04-7 | JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus. |
| CSN22510 | Sograzepide | 155488-25-8 | Sograzepide is a gastrin/cholecystokinin 2 receptor (CCK2) antagonist. |
| CSN22122 | Monacolin J | 79952-42-4 | Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. |
| CSN22411 | GI 181771 | 305366-98-7 | GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity. |
| CSN21395 | PF-06869206 | 2227425-05-8 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| CSN22162 | FK-448 Free base | 85858-76-0 | FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. |
| CSN21399 | Saikogenin A | 5092-09-1 | Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor. |
| CSN22185 | Elobixibat | 439087-18-0 | Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT. |
| CSN22198 | LY377604 | 204592-94-9 | LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. Ly377604 has been used in trials studying the treatment of Obesity. |
| CSN22218 | S-8921 | 151165-96-7 | S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. |
| CSN22397 | Ertiprotafib | 251303-04-5 | Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β), an EC50 of ~1 μM for PPARα/PPARβ. |
| CSN22367 | CDK8-IN-3 | 1884500-15-5 | CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. |
| CSN22395 | EPAC 5376753 | 302826-61-5 | EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. |
| CSN22408 | GC 14 | 447415-34-1 | GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM. |
| CSN22475 | ORL1 Antagonist 1 | 1174985-59-1 | ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM. |
| CSN22489 | Pparδ Agonist | 942594-93-6 | PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10. |
| CSN22490 | Pparδ Agonist 1 | 1902161-12-9 | Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases. |
| CSN22513 | SR 146131 | 221671-61-0 | GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity. |
