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Metabolic Disease

货号 产品名 CAS号 信息
CSN21246 YM-53601 free base 182959-28-0 YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents.
CSN21268 SB-568849 395679-53-5 SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.
CSN21267 YM348 372163-84-3 YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM).
CSN21257 FR194738 free base 204067-45-8 FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
CSN21311 RP 73163 Racemate 136609-53-5 RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
CSN22131 Cort108297 1018679-79-2 Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM.
CSN22389 E-5324 141799-76-0 E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM.
CSN22112 Declaben 111149-90-7 Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
CSN22439 JTT 551 776309-04-7 JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.
CSN22510 Sograzepide 155488-25-8 Sograzepide is a gastrin/cholecystokinin 2 receptor (CCK2) antagonist.
CSN22122 Monacolin J 79952-42-4 Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
CSN22411 GI 181771 305366-98-7 GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.
CSN21395 PF-06869206 2227425-05-8 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
CSN22162 FK-448 Free base 85858-76-0 FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
CSN21399 Saikogenin A 5092-09-1 Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
CSN22185 Elobixibat 439087-18-0 Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.
CSN22198 LY377604 204592-94-9 LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. Ly377604 has been used in trials studying the treatment of Obesity.
CSN22218 S-8921 151165-96-7 S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.
CSN22397 Ertiprotafib 251303-04-5 Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β), an EC50 of ~1 μM for PPARα/PPARβ.
CSN22367 CDK8-IN-3 1884500-15-5 CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.
CSN22395 EPAC 5376753 302826-61-5 EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
CSN22408 GC 14 447415-34-1 GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM.
CSN22475 ORL1 Antagonist 1 1174985-59-1 ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM.
CSN22489 Pparδ Agonist 942594-93-6 PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10.
CSN22490 Pparδ Agonist 1 1902161-12-9 Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
CSN22513 SR 146131 221671-61-0 GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.
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