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CDK
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17512 | XL413 | 1169558-38-6 | XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, > 60-fold selectivity against CK2, > 10-fold selectivity against PIM, and > 300-fold selectivity against a panel of over 100 protein kinases. |
CSN16423 | (S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one xhydrochloride | 1169562-71-3 | XL413 HCl is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, > 60-fold selectivity against CK2, > 10-fold selectivity against PIM, and > 300-fold selectivity against a panel of over 100 protein kinases. |
CSN16984 | WHI-P180 | 211555-08-7 | WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 μM, respectively. |
CSN16220 | THZ1 | 1604810-83-4 | THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 (binding affinity) of 3.2 nM and inhibits Jurkat cell's proliferation with IC50 of 50 nM. |
CSN16121 | TG003 | 719277-26-6 | TG003 is a potent inhibitor of Clk1/Sty and Clk4 with IC50 of 15-20 nM, less potency on Clk2 (IC50= 200 nM). |
CSN16666 | (Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one | 377090-84-1 | SU9516 is a selective and potent CDK2 inhibtor with IC50 of 22 nM, less potent for CDK1/CDK4 (IC50=40/200 nM), and with no inhibition on PKC, EGFR, p38MAPK, etc. |
CSN12378 | SNS-032 | 345627-80-7 | SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
CSN16049 | SCH900776 | 891494-63-6 | SCH 900776 (MK-8776) is a selective and highly potent CHK1 inhibitor with IC50 value of 3nM, modest to CDK2 and Chk2 with much higher IC50 values of 160nM and 1.5uM, respectively. |
CSN11862 | (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol | 186692-46-6 | Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6. |
CSN11862 | (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol | 186692-46-6 | Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6. |
CSN16564 | (Z)-5-(Quinolin-6-ylmethylene)-2-((thiophen-2-ylmethyl)amino)thiazol-4(5H)-one | 872573-93-8 | Ro 3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and > 50-fold relative to CDK4/cyclin D. |
CSN16126 | R547 | 741713-40-6 | R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. |
CSN16119 | Purvalanol B | 212844-54-7 | Purvalanol B is a selective cyclin-dependent kinases (CDKs) inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. |
CSN11800 | Purvalanol A | 212844-53-6 | Purvalanol A is a selective inhibitor of cyclin-dependent kinases (CDKs), it potently inhibits cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35 with IC50 values of 4, 70, 35, 850, and 75 nM respectively. |
CSN12713 | Milciclib | 802539-81-7 | PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM, being > 3-fold selective for CDK2 than CDK1, 2, 4, 5, and 7. |
CSN17186 | PHA-793887 | 718630-59-2 | PHA-793887 is a pan-cdk inhibitor, inhibits cdk1/2/4/5/7/9 with IC50s of 5 - 140 nM. |
CSN16230 | PHA-767491 | 845714-00-3 | PHA-767491 is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM, and also an inhibitor of NRF2. |
CSN15827 | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate | 827022-33-3 | Palbociclib isethionate is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. |
CSN12418 | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | 571190-30-2 | Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM. |
CSN15851 | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride1 | 827022-32-2 | Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. |
CSN16662 | Riviciclib HCl | 920113-03-7 | P276-00 is a CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. |
CSN17748 | Narazaciclib | 1357470-29-1 | ON123300 is a potent and multi-targeted kinase inhibitor which inhibits CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM respectively. |
CSN11589 | NU2058 | 161058-83-9 | NU2058 is a CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1. |
CSN16279 | NG 52 | 212779-48-1 | NG 52 is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM). |
CSN17183 | ML167 | 1285702-20-6 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, showing > 10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. |
CSN23650 | ML 315 | 1440251-53-5 | ML 315 HCl is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B. |
CSN17759 | 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate | 1374639-75-4 | LEE011 Succinate is an orally available cyclin-dependent kinase (CDK) inhibitor with highly selective for cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, and potential antineoplastic activity. |
CSN17760 | Ribociclib succinate hydrate | 1374639-79-8 | LEE011 succinate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
CSN15813 | 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | 1211441-98-3 | LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
CSN17570 | 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride | 1211443-80-9 | LEE011 HCl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
CSN16940 | (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide | 1073485-20-7 | LDC000067 is a highly specific CDK9 inhibitor with IC50 of 32.7 nM for CDK9/cyclin T1. |
CSN12858 | JNJ-7706621 | 443797-96-4 | JNJ-7706621 is a pan-CDK inhibitor that inhibits CDK1/2 with IC50 of 9/4 nM, also potently inhibits Aurora A/B. |
CSN11014 | Flavopiridol | 146426-40-6 | Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively |
CSN11015 | Flavopiridol HCl | 131740-09-5 | Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. |
CSN16417 | CVT-313 | 199986-75-9 | CVT-313 is a potent, selective, ATP-competitive and reversible inhibitor of CDK2 with IC50 of 0.5 μM for Cdk2/A and Cdk2/E; 4.2 μM for Cdk1/B; 215 μM for Cdk4/D1. |
CSN17780 | Cdk9-in-6 | 1391855-95-0 | CDK9-IN-6 is a CDK9 inhibito. |
CSN17642 | CDK9-IN-2 | 1263369-28-3 | CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor with an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively. |
CSN17815 | CDK9-IN-1 | 1415559-43-1 | CDK9-IN-1 is a selective CDK9 inhibitor for the treatment of HIV infection. |
CSN17649 | CDK-IN-2 | 1269815-17-9 | CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of < 8 nM. |
CSN17795 | Ca2+ channel agonist 1 | 1402821-24-2 | Ca2+ channel agonist 1 is a N-type Ca2+ channel activity agonist, with EC50 of 14.23 μM, also inhibits cdk2 kinase activity with EC50 of 3.34 μM. |
CSN17151 | BS-181 HCl | 1397219-81-6 | BS-181 is a selective CDK7 inhibitor with IC50 of 21 nM. |
CSN16513 | BS-181 | 1092443-52-1 | BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. |
CSN16547 | BMS-265246 | 582315-72-8 | BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 and 9 nM respectively. |
CSN16208 | AT7519 | 844442-38-2 | AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB, CDK3/CyclinE, CDK4/CyclinD1 and CDK6/CyclinD3 with IC50 values of 210, 360, 100 and 170nM, respectively. |
CSN16210 | AT7519 HCl | 902135-91-5 | AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7. |
CSN15832 | AMG 925 | 1401033-86-0 | AMG-925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively, and with IC50 of 19 nM in MOLM-13 cell. |
CSN13886 | N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate | 1231930-82-7 | Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers. |
CSN15805 | N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine | 1231929-97-7 | Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers. |
CSN15942 | 1-NM-PP1 | 221244-14-0 | 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 μM for vSrc and 4.2 nM for v-Src-as1 I338G. |
CSN20800 | Senexin A | 1366002-50-7 |