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Histamine Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20447 | VUF10460 | 1028327-66-3 | VUF 10460 is a selective agonist of histamine H4 receptor with pKi of 8.22. |
| CSN21872 | Triprolidine HCl monohydrate | 6138-79-0 | Triprolidine Hydrochloride is the first generation histamine H1 antagonist used in allergic rhinitis. |
| CSN19848 | Thioperamide | 106243-16-7 | Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier. |
| CSN17265 | Setastine | 64294-95-7 | Setastine is an antihistamine used to treat allergies and rhinitis. |
| CSN20599 | S38093 HCl | 1222097-72-4 | S 38093 is an inverse agonist of H3 receptor. |
| CSN21281 | S 38093 | 862896-30-8 | S 38093 is a brain-penetrant antagonist/inverse agonist of H3 receptors. |
| CSN18242 | Pitolisant oxalate | 362665-57-4 | Pitolisant oxalate is a potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM). |
| CSN17352 | Pitolisant | 362665-56-3 | Pitolisant is a potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM). |
| CSN18554 | Pitolisant HCl | 903576-44-3 | Pitolisant HCl is an inverse agonist of human H3 receptor with Ki of 0.16 nM. |
| CSN21315 | Pirolate | 55149-05-8 | Pirolate (CP-32,387) is an antihistamine drug with a tricyclic chemical structure which was patented as an "antiallergen". |
| CSN18828 | 7-Methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one | 484-12-8 | Osthole, an O-methylated coumarin, is a histamine H1 receptor inhibitior. It exhibits immunomodulatory, antioxidative and anti-inflammatory activities. |
| CSN21105 | N-Acetylhistamine | 673-49-4 | N-acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions. |
| CSN17435 | Mizolastine 2HCl | 1056596-82-7 | Mizolastine 2HCl is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. |
| CSN16435 | Mebhydrolin napadisylate | 6153-33-9 | Mebhydrolin Napadisylate is an antihistamine that used for symptomatic relief of allergic symptoms. |
| CSN21134 | Mebhydrolin | 524-81-2 | Mebhydrolin is a specific histamine H1 receptor antagonist. |
| CSN14575 | Marmin | 14957-38-1 | Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro. |
| CSN16072 | Levocetirizine 2HCl | 130018-87-0 | Levocetirizine 2HCl is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. |
| CSN19403 | Ketotifen fumarate salt | 34580-14-8 | Ketotifen fumarate is a noncompetitive H1 receptor antagonist and mast cell stabilizer that is used to treat asthma. |
| CSN20197 | JNJ-10181457 | 544707-19-9 | JNJ10181457 is a histamine H3 receptor inverse agonist that regulates in vivo microglial functions and improves depression-like behaviours in mice. |
| CSN16759 | JNJ-7777120 | 459168-41-3 | JNJ-7777120 is a selective antagonist of histamine-4 receptor (H4R) with Ki of 4 ± 1 nM. |
| CSN17063 | Hydroxyzine | 68-88-2 | Hydroxyzine is a histamine H1-receptor antagonist. |
| CSN16192 | Hydroxyzine 2HCl | 2192-20-3 | Hydroxyzine 2HCl is an antagonist of histamine H1-receptor that inhibits the binding of [3H]pyrilamine and [3H]desloratadine to histamine H1 receptor with IC50s of 10 nM and 19 nM. |
| CSN16747 | 2-(1H-Imidazol-4-yl)ethan-1-amine | 51-45-6 | Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. |
| CSN21410 | H3R antagonist 1 hydrochloride | 2319790-07-1 | H3R-IN-1 HCl is a histamine receptor 3 (H3R) inverse agonist. |
| CSN18994 | GSK189254A | 720690-73-3 | GSK189254A is a potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively. |
| CSN16784 | 3-(((2-Guanidinothiazol-4-yl)methyl)thio)-N-sulfamoylpropanimidamide | 76824-35-6 | Famotidine is antagonist of histamine H2–receptor with IC50 of 0.6 mM that used to treat heartburn and other digestive conditions. |
| CSN19386 | Epinastine | 80012-43-7 | Epinastine is mast cell stabilizer and antihistamine that is used to treat allergic conjunctivitis. |
| CSN19513 | Diphenylpyraline HCl | 132-18-3 | Diphenylpyraline HCl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of Parkinsonism. |
| CSN16168 | Diphenhydramine HCl | 147-24-0 | Diphenhydramine HCl is a histamine H1 antagonist that is used as an antiemetic and antitussive. |
| CSN21346 | Cyclizine | 82-92-8 | Cyclizine, a piperazine derivative, is an antihistaminic antiemetic that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. |
| CSN22573 | Cyclizine 2HCl | 5897-18-7 | Cyclizine is a histamine H1 receptor antagonist of the piperazine class. |
| CSN21347 | Cyclizine HCl | 303-25-3 | Cyclizine HCl is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. |
| CSN20584 | Clobenpropit 2HBr | 145231-35-2 | Clobenpropit hydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier, inhibiting histamine binding in rat brain. |
| CSN15935 | Ciproxifan maleate | 184025-19-2 | Ciproxifan maleate is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
| CSN18049 | Ciproxifan | 184025-18-1 | Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
| CSN22139 | Cipralisant | 213027-19-1 | Cipralisant is a potent and selective histamine H3 receptor antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor; Cipralisant has entered in clinical trials for the treatment of attention-deficit hyperactivity disorder. |
| CSN16377 | Cimetidine | 51481-61-9 | Cimetidine is an antagonist of histamine-2 (H2) receptor. |
| CSN22167 | BMY-25271 | 78441-82-4 | BMY-25271 is a histamine H2 receptor antagonist. |
| CSN25225 | Betahistine | 5638-76-6 | Betahistine is a histamine analog and H1 receptor agonist. |
| CSN17080 | Betahistine 2HCl | 5579-84-0 | Betahistine 2HCl is histamine H3 receptor inhibitor with IC50 of 1.9 μM. It is an antivertigo drug. |
| CSN24137 | Bepotastine | 125602-71-3 | Bepotastine is a non-sedating and selective antagonist of the histamine 1 (H1) receptor. |
| CSN18594 | Bavisant | 929622-08-2 | Bavisant is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. |
| CSN18595 | Bavisant dihydrochloride | 929622-09-3 | Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. |
| CSN17467 | (4-Cyclopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone dihydrochloride hydrate | 1103522-80-0 | Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. |
| CSN16768 | Azelastine | 58581-89-8 | Azelastine is a potent, second-generation, selective, histamine antagonist. |
| CSN16787 | Azelastine HCl | 79307-93-0 | Azelastine HCl is a selective antagonist of histamine receptor used in the treatment of rhinitis. |
| CSN22242 | Antihistamine-1 | 1186430-60-3 | Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. |
| CSN18662 | N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride | 2508-72-7 | Antazoline HCl is a antihistamine with anticholinergic properties. It is used to relieve nasal congestion. |
| CSN23462 | 2-(5-Hydroxy-1H-indol-3-yl)acetic acid | 54-16-0 | 5-Hydroxyindole-3-acetic acid (5-HIAA), the major metabolite of serotonin, is a histamine H1 receptor antagonist and can be used to treat allergies. |
| CSN98768 | 3-(((2-Guanidinothiazol-4-yl)methyl)thio)-N-sulfamoylpropanimidamide | 76824-35-6 |
