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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12495 | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate | 114977-28-5 | Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
| CSN12427 | 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide | 879085-55-9 | Vismodegib is an inhibitor of hedgehog pathway with IC50 of 3 nM and also inhibits P-gp (IC50 = 3.0 μM). |
| CSN12378 | SNS-032 | 345627-80-7 | SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
| CSN12426 | ABT-737 | 852808-04-9 | ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively, showing no inhibition observed against Mcl-1, Bcl-B or Bfl-1. |
| CSN12386 | Selumetinib | 606143-52-6 | Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. |
| CSN12474 | Omipalisib | 1086062-66-9 | GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
| CSN12357 | PD153035 | 153436-54-5 | PD153035 is EGFR inhibitor with Ki and IC50 of 5.2 pM and 29 pM and could rapidly suppress autophosphorylation of EGFR. |
| CSN12358 | N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine | 153436-53-4 | AG-1478 selectively inhibits EGFR with IC50 of 3 nM in cell-free assay. |
| CSN12500 | Combretastatin A4 | 117048-59-6 | Combretastatin A4 is a tubulin polymerization inhibitor with Kd value of 0.4 μM for binding to β-tubulin. |
| CSN12359 | Amlexanox | 68302-57-8 | Amlexanox is a selective inhibitor of TBK1 and IKKε with IC50 values of ~1-2 μM. |
| CSN12366 | 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide 4-methylbenzenesulfonate | 475207-59-1 | Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively. Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro. |
| CSN12370 | Ispinesib | 336113-53-2 | Ispinesib is a quinazolinone-derived, specific and reversible kinesin spindle protein inhibitor with Kiapp value of 1.7 nM. |
| CSN12379 | Avagacestat | 1146699-66-2 | Avagacestat is an inhibitor of γ-secretase Aβ40 and Aβ42 with IC50s of 0.3 nM and 0.27 nM, respectively. |
| CSN12387 | Galeterone | 851983-85-2 | Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. |
| CSN12389 | 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide | 915087-33-1 | Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. |
| CSN12391 | N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide | 918505-84-7 | PLX 4720 is a potent and selective inhibitor of B-RafV600E (IC50=13 nM) and c-Raf-1Y340D/Y341D (IC50=6.7 nM), whth a 10-fold selectivity for B-RafV600E than wild-type B-Raf. |
| CSN12392 | KU-0063794 | 938440-64-3 | KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively) with no effect on PI3Ks. |
| CSN12402 | Linifanib | 796967-16-3 | Linifanib is a potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively. |
| CSN12418 | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | 571190-30-2 | Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM. |
| CSN12420 | (E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | 698387-09-6 | Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. |
| CSN12421 | Luminespib | 747412-49-3 | AUY922 is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1. |
| CSN12422 | NVP-TAE 684 | 761439-42-3 | NVP-TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM in a cell-free assay, 100-fold more sensitive for ALK than InsR. |
| CSN12424 | A-769662 | 844499-71-4 | A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172. |
| CSN12429 | Pictilisib | 957054-30-7 | GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β(11-fold) and p110γ(25-fold). |
| CSN12437 | Bicalutamide | 90357-06-5 | Bicalutamide is non-steroidal androgen receptor antagonist with IC50 value of 190 nM. |
| CSN12454 | Vatalanib 2HCl | 212141-51-0 | Vatalanib 2HCl is inhibitor of VEGFR2 or KDR with IC50 of 37 nM. |
| CSN12461 | BI 2536 | 755038-02-9 | BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3 and also is a BRD4 inhibitor (IC50= 25 nM). |
| CSN12467 | 5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one | 403811-55-2 | 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression and induces cell-cycle arrest and apoptosis. |
| CSN12488 | 4-Acetamido-N-(2-aminophenyl)benzamide | 112522-64-2 | CI-994 is an inhibitor of HDAC1 with IC50 of 0.57 μM with anti-tumor effect. It can cause G1 cell cycle arrest. |
| CSN12523 | Sirtinol | 410536-97-9 | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. |
| CSN12564 | Calcium (4-(((2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate | 1492-18-8 | Leucovorin calcium is a reduced form of folic acid. |
| CSN12578 | (S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-Methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol | 67-97-0 | Vitamin D3, the inactive precursor of calcitriol, is effective in metabolic activation and can be used in treatment of osteoporosis. |
| CSN12486 | 3-Bromopyruvic Acid | 1113-59-3 | 3-Bromopyruvic acid is an inhibitor of hexokinase II with effective antitumor acitvity. |
| CSN12365 | (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione | 517-89-5 | Shikonin is an inhibitor of TMEM16A chloride channel with IC50 of 6.5 μM, it's a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc.. |
| CSN12398 | N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide | 778277-15-9 | GNF-5 is a selective non-ATP competitive inhibitor of Bcr-Abl with IC50 of 220 nM, it's an analogue of GNF-2 with improved pharmacokinetic properties. |
| CSN12371 | (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide | 439081-18-2 | Afatinib is an irreversible inhibitor of pan-ErbB inhibitor with IC50 values of 0.4nM, 0.5nM, 10nM, 14nM and 1nM for EGFR (L858R), EGFR (wt), EGFR (L858R/T790M), HER2 and ErbB4, respectively. |
| CSN12508 | Methyl (2S,4S,E)-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-ethylidene-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydro-2H-pyran-5-carboxylate | 32619-42-4 | Oleuropein is an antioxidant polyphenol isolated from the herb of Olea europaea L.. |
| CSN12444 | 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 170364-57-5 | Enzastaurin is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. |
| CSN12415 | BIX02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| CSN12390 | BRAF inhibitor | 918505-61-0 | BRAF inhibitor is a potent BRAF inhibitor. |
| CSN12393 | 2-(4-((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)-1-morpholinoethan-1-one | 939981-37-0 | p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. |
| CSN12363 | MLN8054 | 869363-13-3 | MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM and exhibits more than 40-fold selective for Aurora A than Aurora B. |
| CSN12385 | AEE788 | 497839-62-0 | AEE788 is an inhibitor of both EGFR and VEGFR, the IC50s for EGFR and ErbB2 is 2 nM, 6 nM respectively. |
| CSN12395 | GSK-1070916 | 942918-07-2 | GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM and displays > 100-fold selectivity against the closely related Aurora A-TPX2 complex (IC50=490 nM). |
| CSN12388 | 4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | 890090-75-2 | Nutlin 3(Random Configuration) is an MDM2 antagonist which can activate p53 pathway through inhibition of p53-MDM2 interaction. |
| CSN12380 | TCS7010 | 1158838-45-9 | Aurora an inhibitor I is a potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold selective for Aurora A than Aurora B. |
| CSN12381 | AZD 6482 | 1173900-33-8 | AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. |
| CSN12399 | Ellipticine | 519-23-3 | Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 1.25±0.13, 0.67±0.06, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.44±0.03, 0.49±0.04, and 1.48±0.62 μM for Breast adenocarcinoma MCF-7, Leukemia HL-60, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-3, Neuroblastoma UKF-NB-4, and Glioblastoma U87MG cell, respectively. |
| CSN12428 | GDC-0879 | 905281-76-7 | GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases. |
