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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12345 | 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one | 763113-22-0 | Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively. |
| CSN12299 | 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine | 446859-33-2 | RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. |
| CSN12352 | Calycosin | 20575-57-9 | Calycosin, a phytoestrogen, is a partial agonist of ER and a calcium channel blocker. It also shows prevention of reperfusion injury. Calycosin can be isolated and purified from the herb of Astragalus membranaceus Bge. var. mongholicus with anti-oxidative activity. |
| CSN12171 | 2,3-Bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1) | 1173097-76-1 | U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM. |
| CSN12302 | (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide | 912444-00-9 | Veliparib is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
| CSN12326 | Tozasertib | 639089-54-6 | Tozasertib is the inhibitor of Aurora-A, -B, -C kinases with Ki values of 0.6, 18, 4.6 nM respectively. |
| CSN12319 | (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine | 877399-52-5 | Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley. |
| CSN12170 | Tyrphostin AG 879 | 148741-30-4 | Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. |
| CSN12304 | Iniparib | 160003-66-7 | BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
| CSN12327 | 6,9-Bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione dimaleate | 144675-97-8 | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone dimaleate is an experimental antineoplastic drug. |
| CSN12330 | Piceatannol | 10083-24-6 | Piceatannol, a natural stilbene, is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb. et Zucc.. |
| CSN12046 | 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide | 85622-93-1 | Temozolomide is a DNA-methylating agent and an alkylating cytostatic drug used in the treatment of some brain cancers, astrocytoma and glioblastoma multiforme. |
| CSN12073 | 2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione | 50-35-1 | Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects. |
| CSN12186 | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine | 443913-73-3 | Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM. |
| CSN12195 | Verteporfin | 129497-78-5 | Verteporfin, a benzoporphyrin derivative monoacid ring A, inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent. |
| CSN12236 | (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride | 119413-54-6 | Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. |
| CSN12259 | Saracatinib | 379231-04-6 | Saracatinib is Src inhibitor with IC50 of 2.7 nM. |
| CSN12260 | 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | 915019-65-7 | BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. |
| CSN12261 | Canertinib | 267243-28-7 | Canertinib is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. |
| CSN12267 | SB 202190 | 152121-30-7 | SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also shows slightly weaker activity for BRD4 (Kd=3.4 μM). |
| CSN12268 | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 280744-09-4 | SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP. |
| CSN12291 | BML-284 | 853220-52-7 | BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity. |
| CSN12295 | 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide hydrochloride hydrate | 923288-90-8 | Nilotinib HCl is a Bcr-Abl inhibitor with IC50 < 30 nM. |
| CSN12308 | 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine | 475110-96-4 | ZSTK474 inhibits class I PI3K isoforms with IC50s of of 16/44/4.6 and 49 nM for PΙ3Κα/β/δ and γ respectively. |
| CSN12309 | Isoalantolactone | 470-17-7 | Isoalantolactone is a naturally occuring sesquiterpene lactone isolated from Inula helenium with a role as an apoptosis inducer, an antifungal agent and a plant metabolite. |
| CSN12314 | BI-D1870 | 501437-28-1 | BI-D1870 is an inhibitor of S6 ribosome which can inhibit RSK1, RSK2, RSK3, RSK4 with IC50 of 31 nM, 24 nM, 18 nM and 15 nM, respectively. |
| CSN12322 | (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | 154229-19-3 | Abiraterone is a potent CYP17A1 inhibitor with IC50 of 4 nM. |
| CSN12341 | Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate | 656247-17-5 | Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. |
| CSN12227 | Lificiguat | 170632-47-0 | Lificiguat is an acivator of guanylyl cyclase (sGC) and can bind to the heme-containing domain of the β subunit with Kd of 0.6 μM - 1.1 μM. |
| CSN12081 | Tri(aziridin-1-yl)phosphine sulfide | 52-24-4 | Thio-TEPA is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate. |
| CSN12047 | Temsirolimus | 162635-04-3 | Temsirolimus directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM. |
| CSN12290 | L-779450 | 303727-31-3 | L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. |
| CSN12100 | TMS | 24144-92-1 | TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). |
| CSN12168 | Tyrphostin A9 | 10537-47-0 | Tyrphostin 9 is a PDGFR inhibitor with IC50 of 0.5 μM EGFR inhibitor with IC50 of 460 μM, it can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations. |
| CSN12049 | (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN12315 | TGX-221 | 663619-89-4 | TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, and is 1000-fold selective for p110β than p110α. |
| CSN12301 | Veliparib 2HCl | 912445-05-7 | Veliparib 2HCl is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
| CSN12131 | Treosulfan | 299-75-2 | Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/mL can be achieved. |
| CSN12201 | Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-9-((2R,4R,6S,8S)-4-(1,1-difluoroethyl)-8-(methoxycarbonyl)-1,3,4,5,6,7,8,9-octahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-3a-ethyl-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate | 162652-95-1 | Vinflunine is a vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. |
| CSN12110 | Tolrestat | 82964-04-3 | Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 value of 35 nM. |
| CSN12139 | Trichostatin A | 58880-19-6 | Trichostatin A is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM and HDAC8 is the only known member of the HDAC-family that is not affected by TSA. |
| CSN12243 | ZM 336372 | 208260-29-1 | ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM. |
| CSN12262 | Masitinib | 790299-79-5 | Masitinib is an inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. |
| CSN12283 | 2,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione | 4707-32-8 | β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC50=0.44 μM). |
| CSN12347 | Elesclomol | 488832-69-5 | Elesclomol, an inhibitor of HSP90, is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. |
| CSN12098 | 7-(Diethylamino)-2-oxo-2H-chromene-3-carboxylic acid | 50995-74-9 | 7ACC1 selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment and inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. |
