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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN10720 | Cyclopamine | 4449-51-8 | Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells. |
| CSN10528 | Fludarabine | 21679-14-1 | Fludarabine, a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies. |
| CSN10851 | Methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate | 89464-63-1 | Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase). |
| CSN10852 | 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid | 117570-53-3 | DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. |
| CSN10931 | Erlotinib | 183321-74-6 | Erlotinib is an EGFR inhibitor with IC50 of 2 nM, > 1000-fold more sensitive for EGFR than human c-Src or v-Abl. |
| CSN10527 | Levoleucovorin Calcium | 80433-71-2 | Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid. |
| CSN10542 | Capsazepine | 138977-28-3 | Capsazepine is an antagonist of TRPV1 receptor with IC50 of 562 nM. It is synthetic analogue of sensory neurone excitotoxin. |
| CSN10595 | Celecoxib | 169590-42-5 | Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM. |
| CSN10645 | 9-β-D-Arabinofuranosylguanine | 38819-10-2 | 9-beta-Arabinosylguanine is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. |
| CSN10653 | Ciprofibrate | 52214-84-3 | Ciprofibrate is an agonist of peroxisome proliferator-activated receptor PPAR⍺. It is used in dyslipidaemia. |
| CSN10693 | (2R,3R,5S)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol | 73-03-0 | Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription. |
| CSN10711 | Cucurbitacin B | 6199-67-3 | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and could repress cancer cell progression. |
| CSN10734 | 4-Amino-1-((2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride | 69-74-9 | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor. |
| CSN10737 | D-alpha-Hydroxyglutaric Acid Disodium | 103404-90-6 | D-alpha-Hydroxyglutaric Acid Disodium is a multiple-target inhibitor of KDM4A and α-Ketoglutarate(α-KG)-dependent dioxygenase, as well as an NF-κB activator. |
| CSN10830 | Diosmetin | 520-34-3 | Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants, and is an agonist of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. |
| CSN10902 | 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione | 476-66-4 | Ellagic acid is a potent and cell permeable casein kinase 2 (CK2) inhibitor with Ki of 20 nM, acts as a potent antioxidant and anti-mutagenic. |
| CSN10903 | Embelin | 550-24-3 | Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay. |
| CSN10512 | Butane-1,4-diyl dimethanesulfonate | 55-98-1 | Busulfan is a bifunctional alkylating agent. |
| CSN10722 | 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide | 50-18-0 | Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
| CSN10473 | BML-190 | 2854-32-2 | BML-190 is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor. |
| CSN10750 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione | 20830-81-3 | Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. |
| CSN10945 | 3CAI | 28755-03-5 | 3CAI is a potent allosteric and specific AKT inhibitor, which exerts efficacy in vitro and in vivo. |
| CSN10712 | Cucurbitacin E | 18444-66-1 | Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis. |
| CSN10482 | Brefeldin A | 20350-15-6 | Brefeldin A inhibits protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus reversibly, can be used to induce autophagy in mammalian cells. |
| CSN10657 | cis-Diaminodichloroplatinum(II) | 15663-27-1 | Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts. It is used, alone or in combination therapy, in the treatment of several types of cancer, including testicular, ovarian, cervical, bladder, and lung cancers. Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth. |
| CSN10932 | Davercin | 55224-05-0 | Erythromycin Cyclocarbonate is a bacteriostatic antibiotic macrolide produced by Streptomyces erythreus which can bind to 50S ribosomal subunits. This will cause inhibition of protein synthesis through inhibiting peptidyl transferase activity and interfering with translocation of amino acids during translation and assembly of proteins. |
| CSN10623 | Chlorotrianisene | 569-57-3 | Chlorotrianisene, a synthetic and non-steroidal estrogen, is a modulator of estrogen receptor. |
| CSN10732 | Cytochalasin B | 14930-96-2 | Cytochalasin B, a metabolite of the fungus Drechslera dematoidea, is an cell-permeable inhibitor of actin polymerization which inhibits cell division, migration and glucose transport and causes G2/M cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma cells. |
| CSN10554 | Carnosol | 5957-80-2 | Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 µM. |
| CSN10802 | Diethyl (Z)-2-butenedioate | 141-05-9 | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB. |
| CSN10751 | Dauricine | 524-17-4 | Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid. |
| CSN10733 | Cytochalasin D | 22144-77-0 | Cytochalasin D, a metabolite of the fungus Drechslera dematoidea, which is about 10-fold more effective than cytochalasin B, inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis. |
| CSN10530 | Calpeptin | 117591-20-5 | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. |
| CSN10702 | Maslinic acid | 4373-41-5 | Maslinic Acid is a byproduct of olive oil extraction exhibiting antiproliferative effect. |
| CSN10498 | N-Benzyl-p-toluenesulfonaMide | 1576-37-0 | BTS is a potent and selective inhibitor of Ca2+-stimulated myosin S1 ATPase with IC50 value of ~5 µM. |
| CSN10918 | Epirubicin | 56420-45-2 | Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting topoisomerase. |
| CSN10983 | Fasudil | 103745-39-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN10522 | trans-C75 | 191282-48-1 | C75 trans is the trans form of C75, which is a potent fatty-acid synthase (FASN) inhibitor with IC50 of 35.4 μM (LNCaP cell Proliferation inhibition). According to the reporter, C75 is a racemic mixture of cis and trans C75 isomers. However, for cis isomer is less soluble in aqueous solutions and the trans isomer of C75 was soluble in culture media, the trans isomer of C75 shows more activity. |
| CSN10551 | cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) | 41575-94-4 | Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism. |
| CSN10853 | DNQX | 2379-57-9 | DNQX is a selective non-NMDA iGluR antagonist. |
| CSN10880 | DY131 | 95167-41-2 | DY131 is an agonist of ERRβ/ERRγ receptor (EC50 = 130 nM) with minimal activity for ERRα, ERα and ERβ. |
| CSN10558 | Cecropin B | 80451-05-4 | Cecropin B can inhibit the expression of CYP3A29. |
| CSN10789 | VAL-083 | 23261-20-3 | VAL-083 is a bi-functional alkylating agent and inhibits U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis. |
| CSN10738 | D609 | 83373-60-8 | D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM) and antiviral and antitumor agent. |
| CSN10978 | Fadrozole | 102676-47-1 | Fadrozole is a selective aromatase inhibitor that has been introduced in Japan for the treatment of breast cancer. |
| CSN10516 | Butein | 487-52-5 | Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. |
| CSN10553 | Carmofur | 61422-45-5 | Carmofur is an antimetabolite used as an antineoplastic agent, it's a derivative of fluorouracil. |
| CSN50084 | 3-((1S,2R,4S,6R)-2,4-Dimethyl-6-vinylcyclohexyl)-1,4-dihydroxypyridin-2(1H)-one | 149196-98-5 |
