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货号 产品名 CAS号 信息
CSN10004 (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 4291-63-8 Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis. For U266, RPMI8226, and MM1.S cells, its IC50 are approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
CSN13468 AKT inhibitor VIII 612847-09-3 Akt inhibitor VIII is a allosterical and isozyme-selective Akt inhibitor with IC50 value of 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3.
CSN17219 18α-Glycyrrhetinic acid 1449-05-4 18α-Glycyrrhetinic acid has been shown to inhibit connexin-26 (gap junction β-2 protein), a tumor suppressor gene expressed in HeLa cells.
CSN21193 Takinib 1111556-37-6 Takinib is a selective TAK1 inhibitor with IC50 of 9.5 nM, it can induce apoptosis in a TNF-α-dependent manner in rheumatoid arthritis (RA) and breast cancer models.
CSN21111 Palupiprant 1369489-71-3 E7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.
CSN21106 Pimozide 2062-78-4 Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; also inhibits STAT3 and STAT5.
CSN18735 A-1331852 1430844-80-6 A1331852 is a potent and selective BCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.
CSN17314 PF-04979064 1220699-06-8 PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC50 of 9.1 nM.
CSN18961 BRD9539 1374601-41-8 BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50.
CSN18799 LB42708 226929-39-1 LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.
CSN22446 LDH-IN-1 1964515-43-2 LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
CSN21088 Withaferin A 5119-48-2
CSN12834 L-778123 HCl 253863-00-2 L-778123 HCl is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.
CSN17383 TAK-593 1005780-62-0 TAK-593 is a potent and selective dual VEGFR/PDGFR inhibitor with IC50s of 3.2/0.95/1.1 nM (VEGFR1/2/3) and 4.3/1/13 nM (PDGFRα/PDGFRα V561D/PDGFRβ) and with an IC50 > 1 μM when tested against more than 200 protein and lipid kinases.
CSN18129 Inolitazone 2HCl 223132-38-5 Inolitazone 2HCl is a high-affinity PPARγ agonist, which activates PPARγ with an EC50 about 1/50 that of rosiglitazone and has no effect on RIE cells that do not express PPARγ.
CSN20355 Tinostamustine 1236199-60-2 EDO-S101 is a pan HDAC inhibitor and inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively.
CSN17324 Mutant IDH1-IN-1 1355326-21-4 Mutant IDH1-IN-1 is a potent mutant IDH1 R132H inhibitor with IC50 < 0.1 μM.
CSN18936 Zabadinostat 934828-12-3 HDAC-IN-4 is a histone deacetylase (HDAC) inhibitor.
CSN18063 KDM5A-IN-1 1905481-36-8 KDM5A-IN-1 is an inhibitor of histone demethylases.
CSN17878 HUHS015 1453097-13-6 HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo.
CSN12733 SU11274 658084-23-2 SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.
CSN12754 Pemetrexed disodium heptahydrate 357166-29-1 Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase.
CSN18128 Inolitazone 223132-37-4 Inolitazone is a high-affinity PPARγ agonist, which activates PPARγ with an EC50 about 1/50 that of rosiglitazone and has no effect on RIE cells that do not express PPARγ.
CSN18525 AZD2932 883986-34-3 AZD2932 is a series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.
CSN12470 Oncrasin-1 75629-57-1 Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.
CSN15814 IU1 314245-33-5 IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.
CSN10699 Corynoline 18797-79-0 (+)-Corynoline is an AChE inhibitor isolated from Corydalis incisa.
CSN18938 NMS-P118 1262417-51-5 NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy with an IC50 of 0.04 μM in HeLa cell.
CSN20175 PKM2 Activator 5 2098951-67-6 PKM2 activator 5 is a pyruvate kinase M2 activator.
CSN20393 T-3775440 HCl 1422535-52-1 T-3775440 is an LSD1 inhibitor which inhibits SCLC cell proliferation by disrupting LDS1 interactions with SNAG domain proteins INSM1 and GFI1B.
CSN22245 Targapremir-210 1049722-30-6 Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.
CSN22223 BAY-524 1445830-39-6 BAY-524 is a Bub1 inhibitor, with an IC50 of 450 nM for human Bub1 in the presence of 2 mM ATP.
CSN22360 BIX-01338 hydrate 1228184-65-3 BIX-01338 hydrate is a histone lysine methyltransferase inhibitor.
CSN22461 Mcl1-IN-3 1814891-79-6 Mcl1-IN-3 is an inhibitor of Mcl1 extracted from patent WO2015153959A2, compound example 57; has an IC50 and Ki of 0.67 and 0.13 μM, respectively.
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