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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12687 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | 943319-70-8 | Ponatinib is a potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
| CSN12700 | PD 153035 HCl | 183322-45-4 | PD153035 HCl is an reversible inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM. |
| CSN12608 | 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one | 2353-33-5 | Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
| CSN12625 | 9-Methoxy-7H-furo[3,2-g]chromen-7-one | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN12630 | 6,7-Dihydroxy-2H-chromen-2-one | 305-01-1 | Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 2.5 µM, respectively. |
| CSN12631 | 4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoic acid | 305-03-3 | Chlorambucil is mainly used in the treatment of chronic lymphocytic leukemia. |
| CSN12634 | (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate | 136572-09-3 | Irinotecan HCl inhibits topoisomerase 1 and prevent DNA from unwinding. |
| CSN12654 | Ethyl 3-amino-4-(cyclohexylamino)benzoate | 347174-05-4 | Ferrostatin-1 is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| CSN12681 | 1-(4-Hydroxy-3-methoxyphenyl)ethanone | 498-02-2 | Apocynin is potent and selective NADPH-oxidase inhibitor with IC50 value of 10 μM. |
| CSN12685 | Foretinib | 849217-64-7 | Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Foretinib is less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and with little activity to FGFR1 and EGFR. |
| CSN12691 | Motesanib | 453562-69-1 | Motesanib is an ATP-competitive inhibitor of VEGFR1 (IC50 = 2 nM), VEGFR2 (IC50 = 3 nM), VEGFR3 (IC50 = 6 nM) and Kit. |
| CSN12695 | Ki16425 | 355025-24-0 | Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. |
| CSN12715 | AT9283 | 896466-04-9 | AT9283 is a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl (T315I), JAK2 and JAK3, Aurora A and Aurora B, respectively. |
| CSN12727 | ZM-447439 | 331771-20-1 | ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src. |
| CSN12732 | Torkinib | 1092351-67-1 | PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM. |
| CSN12742 | N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide | 918504-65-1 | Vemurafenib is a potent inhibitor of B-Raf V600E with IC50 of 31 nM in cell-free assay, and is 10-fold selective for B-Raf V600E over wild-type B-Raf in enzymatic assays while the cellular selectivity can exceed 100-fold. |
| CSN12746 | Calcium N5-methyltetrahydrofolate | 26560-38-3 | Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. |
| CSN12790 | Fosbretabulin disodium | 168555-66-6 | Fosbretabulin disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. |
| CSN12797 | A939572 | 1032229-33-6 | A939572 is an inhibitor of SCD1 with IC50 values of 4 nM and 37 nM for mSCD1 and hSCD1. |
| CSN12815 | (S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid | 58970-76-6 | Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. |
| CSN12862 | Lapatinib ditosylate monohydrate | 388082-78-8 | Lapatinib Ditosylate Hydrate inhibits EGFR and ErbB2 with IC50 of 10.8 nM and 9.2 nM. |
| CSN12870 | 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid | 102121-60-8 | AM580 is the stable retinobenzoic derivative that acts as an agonist of RARα. |
| CSN12886 | Mirdametinib | 391210-10-9 | PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| CSN12740 | Lyn-IN-1 | 887650-05-7 | Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor with potential antineoplastic activity, it is an orally bioavailable 2-phenylaminopyrimidine derivative. |
| CSN12702 | (E/Z)-CP-724714 | 537705-08-1 | CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, > 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. |
| CSN12617 | Gossypol | 303-45-7 | Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins |
| CSN12710 | GW843682X | 660868-91-7 | GW843682X is a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM (PLK1) and 9.1 nM (PLK3) and displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. |
| CSN12858 | JNJ-7706621 | 443797-96-4 | JNJ-7706621 is a pan-CDK inhibitor that inhibits CDK1/2 with IC50 of 9/4 nM, also potently inhibits Aurora A/B. |
| CSN12811 | PHA-680632 | 398493-79-3 | PHA-680632 is potent inhibitor of Aurora A, B and C with IC50 of 27 nM, 135 nM and 120 nM, respectively. |
| CSN12694 | TG101209 | 936091-14-4 | TG 101209 is a potent and selective JAK2 inhibitor with IC50 of 6 nM, also inhibits Flt3 and RET with IC50 values of 25 nM and 17 nM, respectively. |
| CSN12696 | (6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide | 868774-16-7 | ICG-001 is an inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription with IC50 of 3 µM. |
| CSN12885 | Dovitinib lactate hydrate | 915769-50-5 | Dovitinib lactate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. |
| CSN12783 | (-)-gallocatechin | 3371-27-5 | (-)-Gallocatechin, a natural product isolated and purified from the wood of Acacia catechu (L.F.) Willd., has moderate affinity to the human cannabinoid receptor. |
| CSN12728 | Tak-700 | 426219-18-3 | TAK-700 is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits > 1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). |
| CSN12888 | M344 | 251456-60-7 | M344 is HDAC inhibitor with IC50 of 100 nM and can induce cell differentiation. |
| CSN12833 | URB602 | 565460-15-3 | URB-602 is a selective and non-competitive MAGL with IC50 value of 28 µM (rat brain enzyme). |
| CSN12692 | SU14813 | 627908-92-3 | SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). |
| CSN12802 | Mardepodect | 898562-94-2 | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the other PDEs. |
| CSN12670 | Pilaralisib analogue | 956958-53-5 | XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. |
| CSN12796 | Pemetrexed disodium hemipenta hydrate | 357166-30-4 | Pemetrexed disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| CSN12607 | Doxorubicin | 23214-92-8 | Doxorubicin is a topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells. |
| CSN12808 | Dovitinib lactate | 692737-80-7 | Dovitinib lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) with an IC50 of 5 nM. |
| CSN12667 | Tivozanib | 475108-18-0 | Tivozanib is an inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50s of 30 nM, 6.5 nM, 15 nM, respectively. It can also inhibit PDGFR and c-Kit. |
| CSN12658 | SU 5402 | 215543-92-3 | SU5402 is potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. |
| CSN12669 | Brivanib | 649735-46-6 | Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but > 240-fold against PDGFR-β. |
| CSN12716 | GSK461364 | 929095-18-1 | GSK461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM. |
| CSN12713 | Milciclib | 802539-81-7 | PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM, being > 3-fold selective for CDK2 than CDK1, 2, 4, 5, and 7. |
| CSN12593 | C-7280948 | 587850-67-7 | C-7280948 is an inhibitor of PRMT1. |
| CSN12857 | PD173955 | 260415-63-2 | PD173955 is an src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase and is less potent for FGFRα and no activity on InsR and PKC. |
| CSN12856 | Orantinib | 252916-29-3 | TSU-68 is a multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively and has greatest potency against PDGFR autophosphorylation. |
