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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12394 | (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile | 941678-49-5 | Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3. |
| CSN12230 | Dibenzo[cd,g]indazol-6(2H)-one | 129-56-6 | SP-600125 is a competitive and reversible JNK inhibitor with IC50 values of 40 nM, 40 nM and 90 nM for JNK1, 2 and 3. |
| CSN12107 | 2-((3-Chloro-2-methylphenyl)amino)benzoic acid | 13710-19-5 | Tolfenamic acid is a selective COX2 inhibitor with IC50 of 13.49 μM, it's a non-steroidal anti-inflammatory drugs (NSAIDs). |
| CSN12136 | Tribenoside | 10310-32-4 | Tribenoside is a vasoprotective and a mixture of the α- und β-anomers. |
| CSN12172 | Butyl 2-[[3-(Trifluoromethyl)phenyl]amino]benzoate | 67330-25-0 | Ufenamate is a COX inhibitor, used as a topical analgesic. |
| CSN12175 | URB-597 | 546141-08-6 | URB-597 is fatty acid amide hydrolase (FAAH, IC50 = 4.6 nM) inhibitor without effect on other cannabinoid-related targets. |
| CSN12255 | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 520-36-5 | Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM, it's a natural product isolated and purified from the root of Scutellaria indica L.. |
| CSN12300 | 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid | 936727-05-8 | VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation with an EC50 of 0.1 μM. |
| CSN12316 | Rupatadine Fumarate | 182349-12-8 | Rupatadine fumarate is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively. |
| CSN12344 | Valdecoxib | 181695-72-7 | Valdecoxib is a potent COX inhbitor that selectively inhibitors COX-2 with IC50 of 5 nM. |
| CSN12351 | 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one | 491-80-5 | Biochanin A, a phytoestrogen from Trifolium pratense, is an inhibitor of PTK with IC50 of 91.5 μM. It also can be metabolized in vivo to genistein. |
| CSN12359 | Amlexanox | 68302-57-8 | Amlexanox is a selective inhibitor of TBK1 and IKKε with IC50 values of ~1-2 μM. |
| CSN12368 | Parecoxib Sodium | 198470-85-8 | Parecoxib Sodium, a water-soluble and injectable prodrug of valdecoxib, is a COX2 inhibitor used for the short-term treatment of postoperative pain in adults. |
| CSN12374 | Tripelennamine HCl | 154-69-8 | Tripelennamine HCl is an antagonist of H1-receptor that used as a psychoactive drug with antipruritic activity. |
| CSN12449 | Rabeprazole | 117976-89-3 | Rabeprazole, an antiulcer drug, can irreversibly inhibit gastric H+/K+ ATPase pump with IC50 of 72 nM. |
| CSN12480 | 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid | 106685-40-9 | Adapalene is an agonist of RAR-β (Kd = 34 nM), RAR-γ (Kd = 130 nM) and RXR which is used in the treatment of acne. |
| CSN12568 | (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione | 15291-75-5 | Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree. |
| CSN12605 | (S)-2-(6-Methoxynaphthalen-2-yl)propanoic acid | 22204-53-1 | Naproxen is a COX inhibitor for COX1/2 with IC50 of 8.7 and 5.2 μM, respectively. |
| CSN12625 | 9-Methoxy-7H-furo[3,2-g]chromen-7-one | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN12646 | Piroxicam | 36322-90-4 | Piroxicam is a selective COX1 inhibitor with anti-inflammatory effects. |
| CSN12664 | 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene | 110078-46-1 | Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| CSN12665 | 2-((3-(Trifluoromethyl)phenyl)amino)nicotinic acid | 4394-00-7 | Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. |
| CSN12668 | 6-[5-Fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | 841290-80-0 | R406 is an inhibitor of Syk with IC50 of 41 nM. |
| CSN12714 | 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine | 870483-87-7 | GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. |
| CSN12179 | Valethamate bromide | 90-22-2 | Valethamate bromide is generally used as an anticholinergic agent. |
| CSN12622 | Cyclopentyl (3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methyl-1H-indol-5-yl)carbamate | 107753-78-6 | Zafirlukast is the first-approved LTR antagonist with anti-asthmatic and potential capsular contracture-preventing activities. |
| CSN12048 | Tenatoprazole | 113712-98-4 | Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. |
| CSN12050 | Tenoxicam | 59804-37-4 | Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. |
| CSN12600 | AMI-1 | 20324-87-2 | AMI-1 is an inhibitor of protein arginine N-methyltransferases (PRMTs) with IC50 of 8.8 μM for PRMT1 via blocking peptide-substrate binding. |
| CSN12289 | QNZ | 545380-34-5 | QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively. |
| CSN12193 | Vasicine | 6159-55-3 | Vasicine, a natural product isolated and purified from the leaves of Adhatoda vasica, is a potential cholinesterase inhibitor in development for treatment of Alzheimer's disease, and can regulate the inflammatory reaction. |
| CSN12482 | Mizolastine | 108612-45-9 | Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. |
| CSN12056 | 1-(4-(tert-Butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol | 50679-08-8 | Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM. |
| CSN12285 | Yangonin | 500-62-9 | Yangonin, a natural product isolated and purified from the roots of Piper methysticum, possess significant binding affinity for the cannabinoid receptor CB1 and inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. |
| CSN12016 | Sulindac | 38194-50-2 | Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) and is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis. |
| CSN12231 | Zardaverine | 101975-10-4 | Zardaverine is a dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively. |
| CSN12592 | Amcinonide | 51022-69-6 | Amcinonide inhibit NO release from activated microglia with IC50 3.38 nM. |
| CSN12220 | Xanthotol | 2009-24-7 | Xanthotoxol, a natural product isolated and purified from the fruits of Cnidium monnieri, has neuroprotection, due to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia. |
| CSN12018 | Suplatast (Tosilate) | 94055-76-2 | Suplatast Tosylate is an inhibitor of Th2 cytokine synthesis which can attenuate IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. |
| CSN12122 | Tranilast | 53902-12-8 | Tranilast can antagonize angiotensin II and also work as an antiallergic agent. It showed inhibitory effect for NLRP3 inflammasome but not for NLRC4 or AIM2 inflammasome. Tranilast impaired the endogenous NLRP3-ASC interaction but did not affect the NLRP3-NEK7 interaction, raising the possibility that it targets NLRP3 directly. |
| CSN12237 | Zileuton | 111406-87-2 | Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 µM in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 µM in purified human peripheral blood polymorphonuclear leukocytes (PMNL). |
| CSN12321 | 2-Amino-2-(4-octylphenethyl)propane-1,3-diol | 162359-55-9 | Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. |
| CSN12396 | SC-58125 | 162054-19-5 | SC 58125 is a selective, time-dependent, and irreversible cyclooxygenase-2 (Cox-2) inhibitor that displays anti-inflammatory properties. |
| CSN12051 | Teprenone | 6809-52-5 | Teprenone is used as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. |
| CSN50147 | Glycine, (βR)-2-[(R)-[(2S,4S)-4-amino-4-carboxy-2-hydroxybutyl]sulfinyl]-β,5-dihydroxy-N-methyl-L-tyrosyl-L-valyl-3-hydroxy-L-isoleucyl-, cyclic (15→3)-ether | 143557-93-1 |
