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Inflammation/Immunology

货号 产品名 CAS号 信息
CSN11454 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxy-1H-imidazole-4-carboxamide 50924-49-7 Mizoribine is an immunosuppressive agents (IC50=100 μM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
CSN11455 Montelukast Sodium 151767-02-1 Montelukast Sodium is a potent, selective and competitive LTR1 antagonist with IC50 value < 5 nM, possesssing anti-inflammatory and bronchodilating activities.
CSN11857 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 162401-32-3 Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM.
CSN11136 Halofuginone 55837-20-2 Halofuginone is an inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/mL in mammal.
CSN11203 3,7,11-Trimethyldodeca-2,6,10-trien-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate 85801-02-1 Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug indometacin.
CSN11220 Acteoside 61276-17-3 Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 =25 μM).
CSN11252 2-(3-Benzoylphenyl)propanoic acid 22071-15-4 Ketoprofen is a dual COX1/2 inhibitor with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively, and used as a nonsteroidal anti-inflammatory drug (NSAID) to treat arthritis-related inflammatory pains.
CSN11309 Roquinimex 84088-42-6 Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha.
CSN11321 Lodoxamide tromethamine 63610-09-3 Lodoxamide tromethamine is used as an ophthalmic solution that specially applying to the eye.
CSN11332 Lornoxicam 70374-39-9 Lornoxicam is a COX inhibitor with IC50 of 5 nM and 8 nM for COX1 and 2 respectively. It's a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of various types of pain.
CSN11334 Loteprednol Etabonate 82034-46-6 Loteprednol etabonate is a corticosteroid with anti-inflammatory effect that is used in optometry and ophthalmology.
CSN11337 Loxoprofen 68767-14-6 Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and propionic acid derivative.
CSN11361 Maraviroc 376348-65-1 Maraviroc is a selective CCR5 antagonist (IC50= 6.4 nM) and displays potent anti-HIV-1 activity.
CSN11372 Mefenamic Acid 61-68-7 Mefenamic Acid is an inhibitor of COX2 with anti-inflammatory properties, it's a non-steroidal anti-inflammatory agent.
CSN11503 4-(6-Methoxynaphthalen-2-yl)butan-2-one 42924-53-8 Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and its active metabolite inhibits the COX.
CSN11548 (E/Z)-Teriflunomide 108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN11565 Nizatidine 76963-41-2 Nizatidine is an antagonist of histamine H2 receptor that can inhibit the secretion of gastric acid.
CSN11586 NS-398 123653-11-2 NS-398 is a selective inhibitor of COX2 with IC50s of 75 and 1.77 μM for human recombinant COX1 and 2 respectively.
CSN11604 Olopatadine HCl 140462-76-6 Olopatadine HCl can block the release of histamine (IC50 = 559 µM) and stabilize mast cell.
CSN11614 Nimesulide 51803-78-2 Nimesulide is a COX2 selective inhibitor with IC50 of 26 μM.
CSN11761 Pranlukast 103177-37-3 Pranlukast is a selective CysLt1 leukotriene receptor antagonist.
CSN11767 Prednisolone Acetate 52-21-1 Prednisolone 21-acetate is the acetate form of prednisone which is a synthetic corticosteroid with immunosuppressant and anti-inflammatory activities.
CSN11824 Rabeprazole Sodium Salt 117976-90-6 Rabeprazole sodium is an inhibitor of proton pump with antiulcer activities.
CSN12011 Sulfasalazine 599-79-1 Sulfasalazine is a potent and specific NF-κB inhibitor and also inhibits system Xc and induces ferroptosis.
CSN11668 Pemirolast potassium 100299-08-9 Pemirolast potassium is an antagonist of histamine H1 and mast cell stabilizer with antiallergic effect.
CSN11523 Sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate 26159-34-2 Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
CSN11875 Rupatadine 158876-82-5 Rupatadine is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes).
CSN11224 Pasiniazid 2066-89-9 Pasiniazid is a composition of isoniazid and 4-aminosalicylic acid, that has mutual effects coupling isoniazid and 4-aminosalicylic acid for use in tuberculosis patients.
CSN11177 Hydroxyzine pamoate 10246-75-0 Hydroxyzine pamoate is a histamine H1-receptor antagonist.
CSN11597 Octreotide acetate 79517-01-4 Octreotide acetate is a long-acting octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin.
CSN11301 Limaprost 74397-12-9 Limaprost is a PGE1 analog and potent platelet adhesion inhibitor.
CSN11226 4-Isopropylantipyrine 479-92-5 Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
CSN11540 Nepafenac 78281-72-8 Nepafenac is a selective COX2 inhibitor and is prodrug of amfenac used in the treatment of pain and inflammation associated with cataract surgery.
CSN11691 Pheniramine maleate 132-20-7 Pheniramine maleate can acts as an antihistamine and vasoconstrictor.
CSN11744 Polyinosinic acid-polycytidylic acid 24939-03-5 Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
CSN11701 Phorbol 12-myristate 13-acetate 16561-29-8 Phorbol 12-myristate 13-acetate is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.
CSN11167 Hydrocortisone 17-butyrate 13609-67-1 Hydrocortisone 17-butyrate is an adrenocortico hormone
CSN11294 Lexacalcitol 131875-08-6 Lexacalcitol is over 100 times more active than 1alpha, 25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3], as judged by in vitro antiproliferative and cell differentiating assays.
CSN11768 Disodium Prednisolone 21-Phosphate 125-02-0 Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
CSN11130 GW1929 196808-24-9 GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPARγ, respectively.
CSN11122 Guacetisal 55482-89-8 Guacetisal is a drug that has been used to treat inflammatory respiratory diseases.
CSN11382 Mequitazine 29216-28-2 Mequitazine is a potent, nonsedative and long-acting histamine H1 antagonist.
CSN11915 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid 112665-43-7 Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist.
CSN11253 2-Amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate 74103-07-4 Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
CSN11286 Lestaurtinib 111358-88-4 Lestaurtinib is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic derivative of the indolocarbazole K252a was investigated by Cephalon as a treatment for various types of cancer.
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