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Neurological Disease

货号 产品名 CAS号 信息
CSN12946 (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride 78246-49-8 Paroxetine HCl is a selective serotonin-reuptake inhibitor (SSRI) with antidepressant activity.
CSN13046 Scopine HCl 85700-55-6 Scopine HCl salt is a naturally occuring α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock and also s a potential brain-targeting moiety for enhancing the brain uptake efficiency of chlorambucil.
CSN13111 SB 242084 2HCl 1049747-87-6 SB-242084 2HCl is a selective and brain-penetrant antagonist for the 5HT2C receptor.
CSN13137 Ondansetron 99614-02-5 Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
CSN13164 Tozadenant 870070-55-6 Tozadenant is a selective adenosine A2A receptor antagonist with Ki values of 11.5 nM on human A2A and 6 nM on rhesus A2A, which can improve motor function in animal models of Parkinson's disease.
CSN13179 (R)-(-)-Rolipram 85416-75-7 (R)-(-)-rolipram, R-enantiomer of rolipram, is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 μM and 2.5-fold more potent than(+)-rolipram (IC50= 2.58 μM) in inhibiting membrane-bound PDE 4.
CSN13513 Alvimopan 156053-89-3 Alvimopan is a peripherally selective opioid mu receptor antagonist.
CSN13580 Omberacetam 157115-85-0 Noopept is a potent nootropic that improves cognitive ability.
CSN13642 (R)-2-(2-Aminothiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide 223673-61-8 Mirabegron is an agonist of β3 adrenergic receptor with EC50 value of 22.4nM, used for the treatment of overactive bladder.
CSN13756 Histamine 2HCl 56-92-8 Histamine 2HCl is the 2HCl form of histamine which is an organic nitrogen compound that articipates in immune responses and inflammatory reactions and also can be used as neurotransmitters
CSN13721 Org 27569 868273-06-7 Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity.
CSN13419 CPPHA 693288-97-0 CPPHA is a selective positive allosteric modulator of mGluR5 receptor.
CSN13119 2-PMPA 173039-10-6 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.
CSN13735 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride 14919-77-8 Benserazide HCl is a aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
CSN13677 Tetrabenazine Racemate 718635-93-9 Tetrabenazine Racemate is a potent, selective and reversible VMAT-2 (vesicular monoamine transporter-2) inhibitor with Ki value of 100 nM. Tetrabenazine Racemate is a racemic mixture.
CSN13136 Venlafaxine HCl 99300-78-4 Venlafaxine HCl is an inhibitor of serotonin/noradrenalin re-uptake and is used as an antidepressive agent.
CSN13005 BMY 7378 21102-95-4 BMY 7378 2HCl is a 5-HT1A partial agonist and a high-affinity α1D adrenoceptor antagonist with Ki values of 2, 800 and 600 nM for cloned rat α1D, rat α1A and hamster α1B receptors respectively.
CSN13669 (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate 191217-81-9 Pramipexole 2HClis a non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
CSN13078 4-(2-(Dipropylamino)ethyl)indolin-2-one hydrochloride 91374-20-8 Ropinirole HCl selectively inhibit dopamine D2 receptor with Ki of 29 nM. It is used for the treatment of spontaneous parkinson's disease.
CSN12986 Buspirone 36505-84-7 Buspirone is an anxiolytic drug that is primarily used to treat generalized anxiety disorder (GAD).
CSN13188 PD 117519 96392-15-3 PD117519 is an adenosine agonist.
CSN13779 Filorexant 1088991-73-4 MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor (< 3 nM in binding).
CSN13626 Encenicline 550999-75-2 EVP-6124 is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) and shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.
CSN13170 MK-3207 957118-49-9 MK-3207 is a potent and orally bioavailable CGRP receptor antagonist (IC50= 0.12 nM; Ki value= 0.024 nM), showing highly selective versus human AM1, AM2, CTR, and AMY3.
CSN13650 Alvimopan dihydrate 170098-38-1 Alvimopan is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
CSN13695 MDL-29951 130798-51-5 MDL-29951 is a glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo.
CSN13615 Ro 61-8048 199666-03-0 Ro 61-8048 is an inhibitor of kynurenine 3-hydroxylase which can potently and competitively inhibit kynurenine 3-monooxygenase with Ki value and IC50 value of 4.8 nM and 37 nM, respectively.
CSN13647 MTEP HCl 1186195-60-7 MTEP HCl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
CSN13776 Bay 60-7550 439083-90-6 BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human), being 50-fold selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5, PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.
CSN13591 Talampanel 161832-65-1 Talampanel, a potent and selective AMPA-receptor antagonist, is a potential antiepileptic drug (AED).
CSN13121 SB-269970 HCl 261901-57-9 SB-269970 HCl is a HCl salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3 and exhibits > 50-fold selectivity against other receptors.
CSN13508 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide 439239-90-4 Lasmiditan is a high-affinity, highly selective 5-HT1F receptor agonist (Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively.
CSN13718 Rotigotine HCl 125572-93-2 Rotigotine HCl is an agonist of dopamine D2 receptor and dopamine D3 receptor with Ki of 13 and 0.71 nM respectively.
CSN13092 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride 82752-99-6 Nefazodone HCl is a 5-HT2A receptor antagonist with Ki of 5.8 nM and an inhibitor of serotonin and noradrenalin uptake with IC50s of 290 and 300 nM respectively, it is an antidepressant drug.
CSN12978 Traxoprodil 134234-12-1 Traxoprodil a selective antagonist of the NR2B subunit of the NMDA receptor.
CSN13073 Tropisetron 89565-68-4 Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
CSN13085 Venlafaxine 93413-69-5 Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
CSN13107 A-740003 861393-28-4 A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively).
CSN13120 LY 344864 186544-26-3 LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
CSN13169 MK-3207 HCl 957116-20-0 MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3
CSN13452 Nepicastat HCl 170151-24-3 Nepicastat HCl is a potent and selective dopamine β-hydroxylase (DBH) inhibitor with IC50 value of 9 nM.
CSN13678 Talnetant 174636-32-9 Talnetant is a potent and selective NK3 receptor antagonist (ki=1.4 nM, hNK-3-CHO), and is 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 μM.
CSN13503 Cebranopadol 863513-91-1 Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.
CSN13576 SKF 38393 HCl 62717-42-4 SKF-38393 HCl is an agonist of dopamine D1 receptor (the IC50 value is 110 nM). It has anorectic and stimulant effects.
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