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Neurological Disease

货号 产品名 CAS号 信息
CSN12085 Tiagabine HCl 145821-59-6 Tiagabine HCl is an inhibitor of gamma-aminobutyric acid (GABA) reuptake (IC50 = 67 nM in vivo) with anticonvulsant effect.
CSN12106 Tolcapone 134308-13-7 Tolcapone is a potent, selective and orally active catechol-O-methyltransferase (COMT) inhibitor with Ki of 30 nM.
CSN12156 Tropicamide 1508-75-4 Tropicamide is a mAchR M4 antagonist, used to dilate the pupil and help with examination of the eye.
CSN12242 ZM241385 139180-30-6 ZM241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.
CSN12268 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 280744-09-4 SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP.
CSN12336 Fosaprepitant Dimeglumine 265121-04-8 Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.
CSN12463 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one 129722-12-9 Aripiprazole is a multiple-target agent used to treat schizophrenia and bipolar disorder, working as both a silent antagonist and a high-efficacy partial agonist of D2 receptor, as well as works as a partial agonist of 5-HT1A/5-HT2A, 5-HT2 receptor,a potent inverse agonist of 5-HT2B receptor, a functional antagonist of 5-HT7 receptor.
CSN12476 (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 104632-26-0 Pramipexole is an agonist of dopamine receptors D2, D3, and D4 (Ki = 3.9, 2.2, 0.5, and 5.1 nM respectively) and it is indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).
CSN12479 Risperidone 106266-06-2 Risperidone is a multiple-target antipsychotic with high affinity for 5-HT2A and D2 receptors, alpha 1, alpha 2 and H1 receptors.
CSN12491 Mosapride 112885-41-3 Mosapride a selective 5HT4 agonist used as a gastroprokinetic agent.
CSN12506 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride 120011-70-3 Donepezil HCl is a selective and reversible AchE inhibitor, highly selective for the central nervous system and used in the management of mild to moderate Alzheimer's disease and dementia.
CSN12312 Fluvoxamine maleate 61718-82-9 Fluvoxamine maleate is a selective serotonin reuptake inhibitor and can be used as an antidepressant.
CSN12144 N,N-Dimethyl-3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propan-1-amine hydrochloride 1098-60-8 Triflupromazine HCl, an antipsychotic, can function as a blocker of dopamine D2 receptor and dopamine D3 receptor in brain. It is used to treat dyskinesia and alcohol withdrawal syndrome.
CSN12483 Pyrithioxin 1098-97-1 Pyrithioxin is a a nootropic.
CSN12425 ADL-5859 Hydrochloride 850173-95-4 ADL-5859 HCl is both a δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM) and selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel with IC50 value of 78 µM.
CSN12099 Tizanidine HCl 64461-82-1 Tiamenidine HCl is a centrally-acting α1 and α2 adrenergic receptor antagonist with IC50 4.85 μM and 0.0091 μM, respectively, for the management of essential hypertension.
CSN12115 Topiramate 97240-79-4 Topiramate is a selective GluK1 kainate receptors (GluR5) antagonist with IC50 value of 0.46 μM which can act as a positive allosteric modulator of GABAA receptor-mediated currents, inhibit Nav channels and L-type Ca2+ channels.
CSN12193 Vasicine 6159-55-3 Vasicine, a natural product isolated and purified from the leaves of Adhatoda vasica, is a potential cholinesterase inhibitor in development for treatment of Alzheimer's disease, and can regulate the inflammatory reaction.
CSN12475 Sumatriptan succinate 103628-48-4 Sumatriptan Succinate can selectively bind to and activate 5-HT1 receptors.
CSN12419 LY404039 635318-11-5 LY404039 is an inhibitor for mGluR1 (Ki=149 nM) and mGluR2 (Ki= 92 nM), which can also inhibit dopamine receptor.
CSN12088 Tiapride HCl 51012-33-0 Tiapride HCl is a drug that selectively blocks D2 and D3 dopamine receptors in the brain.
CSN12150 Trimipramine maleate 521-78-8 Trimipramine maleate is a serotonin transport and norepinephrine uptake blocker, is a tricyclic antidepressant (TCA) with antipsychotic and sedative properties.
CSN12361 ABT-239 460746-46-7 ABT-239 is a highly efficacious, non-imidazole class of H3R antagonist.
CSN12443 Galanthaminone 510-77-0 Galantamine is a competitive and reversible cholinesterase (AChE) inhibitor and is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
CSN12251 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate 375815-87-5 Varenicline tartrate is a nicotinic receptor partial agonist and it stimulates nicotine receptors more weakly than nicotine itself does.
CSN12109 Tolperisone HCl 3644-61-9 Tolperisone HCl is a muscle relaxant and an ion channel blocker with antispastic function.
CSN12407 Loxapine 1977-10-2 Loxapine succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
CSN12124 Asenapine 65576-45-6 Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
CSN12436 SAR7334 HCl 1333207-63-8 SAR7334 2HCl is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
CSN12191 Varenicline 249296-44-4 Varenicline is a selective α4β2 nicotinic receptor partial agonist and it stimulates nicotine receptors more weakly than nicotine itself does.
CSN12068 Tetrahydroberberine,THB 522-97-4 Tetrahydroberberine is an isoquinoline alkaloid isolated and purified from the barks of Phellodendron chinense Schneid. It has micromolar affinity for dopamine D(2) (pK (i) = 6.08) and 5-HT(1A) (pK (i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors(5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK (i) < 5.00).
CSN12084 Tiagabine 115103-54-3 Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
CSN12143 Trifluoperazine 117-89-5 Trifluoperazine is a typical antipsychotic of the phenothiazine chemical class.
CSN12157 Trospium chloride 10405-02-4 Trospium chloride is a competitive antagonist at muscarinic cholinergic receptors, used to treat symptoms of an overactive bladder.
CSN12187 1-(2-(Bis(4-Fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine 67469-69-6 Vanoxerine is a potent and selective DRI (dopamine reuptake inhibitor).
CSN12237 Zileuton 111406-87-2 Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 µM in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 µM in purified human peripheral blood polymorphonuclear leukocytes (PMNL).
CSN12245 (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one 139264-17-8 Zolmitriptan is an agonist of 5-HT1B/5-HT1D receptors with anti-migraine properties.
CSN12306 Tasimelteon 609799-22-6 Tasimelteon is a melatonin MT1 and MT2 receptor agonist.
CSN12360 Desfesoterodine 207679-81-0 (R)-5-Hydroxymethyl tolterodine is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively.
CSN12364 Lurasidone HCl 367514-88-3 Lurasidone HCl is a multiple-target antagonist of dopamine D2 receptor, 5-HT2 receptor, 5-HT7 receptor, adrenergic α2A and α2C receptors, also works as a partial 5-HT1A receptor agonist. It used as an atypical antipsychotic medication for the treatment of several mental disorders.
CSN12416 Fesoterodine fumarate 286930-03-8 (R)-Fesoterodine fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
CSN12462 Fexofenadine HCl 153439-40-8 Fexofenadine inhibits histamine H1 receptor with IC50 of 246 nM.
CSN12499 Duloxetine HCl 136434-34-9 Duloxetine HCl is an inhibitor of serotonin-norepinephrine reuptake with Ki of 4.6 nM and used to treat depressive and anxiety disorders.
CSN12059 Desmethoxyyangonin 15345-89-8 Desmethoxyyangonin is a natural kavalactones isolated and purified from the Piper methysticum (kava) plant which is an ireversible inhibitor of MAO-B.
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