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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12512 | 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione | 122320-73-4 | Rosiglitazone is a selective agonist of PPARγ with EC50 of 60 nM, and has no effect on PPARα and PPARβ. It is an insulin sensitizing and potent antihyperglycemic agent. |
| CSN12514 | 6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide hydrochloride | 123040-16-4 | Azasetron HCl is a potent, selective and competitive 5-HT3 receptor antagonist with pKi value of 9.27. |
| CSN12534 | Tiotropium Bromide | 136310-93-5 | Tiotropium bromide is amAChR antagonist which acts through blocking the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. |
| CSN12554 | Pregnenolone | 145-13-1 | Pregnenolone is an endogenous steroid hormone synthesized from cholesterol which can act either as a neuroactive steroid or as a prohormone for progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens, and the neuroactive steroids. |
| CSN12577 | Azaperone | 1649-18-9 | Azaperone functions as a dopamine antagonist that can bind to D1 and D2 receptors. It has the characteristics of antihistamines and anticholinergics. |
| CSN12584 | 6-(Trifluoromethoxy)benzo[d]thiazol-2-amine | 1744-22-5 | Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis. |
| CSN12675 | Coluracetam | 135463-81-9 | Coluracetam a nootropic which can increase the potency of AMPA receptors. |
| CSN12701 | TRAM-34 | 289905-88-0 | TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). |
| CSN12717 | Preladenant | 377727-87-2 | Preladenant is a highly selective and competitive A2A receptor antagonist with Ki value of 1.1nM, used in trials studying the treatment of brain diseases, such as parkinson disease, movement disorders, antipsychotic agents and parkinsonian disorders. |
| CSN12745 | Naratriptan HCl | 143388-64-1 | Naratriptan HCl is a selective sulfonamide 5-HT1D and 5-HT1B receptor agonist with anti-migraine property . |
| CSN12749 | Diphenidol HCl | 3254-89-5 | Diphenidol HCl is a non-selective mAchR antagonist and also works as a non-specific inhibitor of voltage-gated ion channels (Na+, K+, and Ca2+) in neurons. |
| CSN12750 | (R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride | 82248-59-7 | Atomoxetine HCl is a phenoxy-3-propylamine-derived and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. |
| CSN12774 | 1-(2-Hydroxy-4-methoxyphenyl)ethanone | 552-41-0 | Paeonol is a naturally occuring MAO inhibitor with IC50 values of 54.6 μM and 42.5 μM for MAO-A and MAO-B, respectively. |
| CSN12782 | 4-Aminobutyric acid | 56-12-2 | 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter. |
| CSN12817 | N-Methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride | 56296-78-7 | Fluoxetine HCl, an antidepressant, is an inhibitor of the selective serotonin reuptake with Kd of 0.81 nM against serotonin transporter. |
| CSN12825 | 2-(1-(Aminomethyl)cyclohexyl)acetic acid | 60142-96-3 | Gabapentin is an analogue of GABA that used to treat seizures and neuropathic pain. |
| CSN12876 | LY310762 | 192927-92-7 | LY310762 is a potent and selective antagonist for the 5-HT1D serotonin receptor with EC50 value of 31 nM. |
| CSN12748 | Ziprasidone HCl | 122883-93-6 | Ziprasidone HCl is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity, and is used in the treatment of schizophrenia and bipolar disorder. |
| CSN12586 | (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)methanone methanesulfonate | 131543-23-2 | WIN 55212-2 mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. |
| CSN12849 | (6-Iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)(4-methoxyphenyl)methanone | 164178-33-0 | AM630 is a selectivity CB2 antagonist with Ki of 31.2 nM with a > 150 fold selectivity over CB1 receptor. |
| CSN12847 | RS-127445 HCl | 199864-86-3 | RS-127445 is a selective, high affinity and orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 is found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. |
| CSN12812 | Ziprasidone HCl monohydrate | 138982-67-9 | Ziprasidone HCl H2O is a full antagonist of D2 receptors and of 5-HT2A receptors and is a partial agonist of 5-HT1A receptors, of 5-HT2C receptors and 5-HT1D receptors, used as an atypical antipsychoticfor the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder. |
| CSN12731 | Dimenhydrinate | 523-87-5 | Dimenhydrinate is an anti-emetic and anti-histamine. |
| CSN12604 | Escitalopram oxalate | 219861-08-2 | Escitalopram Oxalate is an inhibitor of selective serotonin reuptake with Ki of 0.89 nM. |
| CSN12795 | 5,5-Diphenylhydantoin | 57-41-0 | Phenytoin is an inactive voltage-gated sodium channel stabilizer. |
| CSN12526 | Ropivacaine HCl monohydrate | 132112-35-7 | Ropivacaine HCl, a local anaesthetic, can reversibly inhibit sodium ion influx and block impulse propagation along nerve fibres. |
| CSN12652 | trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate | 85650-56-2 | Asenapine Maleate is a 5-HT and dopamine D2 receptor antagonist used to treat schizophrenia and bipolar mania. |
| CSN12547 | Bupivacaine HCl | 18010-40-7 | Bupivacaine HCl is a local anaesthetic drug belonging to the amino amide group. |
| CSN12547 | Bupivacaine hydrochloride | 18010-40-7 | |
| CSN12709 | (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione | 155270-99-8 | Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist (Ki=2.2 nM) in experimental models of Parkinson's disease. |
| CSN12723 | Sumanirole maleate | 179386-44-8 | Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. |
| CSN12516 | Tolterodine | 124937-51-5 | Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. |
| CSN12511 | Naratriptan | 121679-13-8 | Naratriptan is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches. |
| CSN12899 | (R)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine | 104632-28-2 | Dexpramipexole is a neuroprotective agent and weak non-ergoline dopamine agonist. |
| CSN12768 | Fluvoxamine | 54739-18-3 | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. |
| CSN12690 | CX546 | 215923-54-9 | CX-546 is a AMPAR potentiator which can destabilize the desensitized receptor conformation. |
| CSN12543 | rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide xhydrate | 139404-48-1 | Tiotropium bromide is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. |
| CSN12597 | Trazodone HCl | 25332-39-2 | Trazodone HCl is a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist, used as an antidepressant medication. |
| CSN12542 | Ziprasidone | 146939-27-7 | Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. |
| CSN12929 | Vortioxetine HBr | 960203-27-4 | Vortioxetine HCl, a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. |
| CSN12635 | (1S,2R,3R,4aS,13bR,14aS)-Methyl 2,11-dimethoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate | 50-55-5 | Reserpine is a naturally occuring brain-penetrant and irreversible VMAT (vesicular monoamine transporter 1 and 2) antagonist. |
| CSN12643 | Vecuronium bromide | 50700-72-6 | Vecuronium bromide is a competitive AchR inhibitor and binds to cholinergic receptors at neuromuscular junctions, used as an aminosteroidal neuromuscular blocking agent. |
| CSN12682 | Scopine | 498-45-3 | Scopine is a naturally occuring α1-adrenergic receptor agonist which is the metabolite of anisodine, used in the treatment of acute circulatory shock. |
| CSN12786 | Trazodone | 19794-93-5 | Trazodone is an antidepressant of the serotonin antagonist and reuptake inhibitor (SARI) class. |
| CSN12810 | LY2811376 | 1194044-20-6 | LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. |
| CSN12920 | Safinamide mesylate | 202825-46-5 | Safinamide mesylate is mesylate salt of safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, and exhibits 5918-fold selectivity against MAO-A. |
| CSN12928 | Vortioxetine | 508233-74-7 | Vortioxetine is a 5-HT3, 5-HT1D, and 5-HT7 antagonist, a 5-HT1A agonist, and a 5-HT1B partial agonist. |
| CSN12931 | 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine | 75438-57-2 | Moxonidine is a selective agonist of imidazoline I1 receptors and alpha-2 receptor used as an antihypertensive drug. |
