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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12447 | Fondaparinux sodium | 114870-03-0 | Fondaparinux sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa (IC50 = 40 nM). It can bind to antithrombin III. |
| CSN12445 | Enalapril Maleate | 76095-16-4 | Enalapril maleate is a prodrug ACE inhibitor, which can be rapidly metabolized in the liver to enalaprilat. |
| CSN12515 | Losartan potassium | 124750-99-8 | Losartan Potassium is the potassium salt form of Losartan, which is a compeitive AT1 receptor inhibitor with IC50 value of 20 nM. |
| CSN12536 | (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid | 137862-53-4 | Valsartan is a selective angiotensin II AT1 receptor antagonist with elimination half-life of 6 hours. |
| CSN12537 | Irbesartan | 138402-11-6 | Irbesartan is a selective and competitive nonpeptide angiotensin II antagonist with antihypertensive activity. |
| CSN12544 | Candesartan | 139481-59-7 | Candesartan is a benzimidazole-derived and competitive AT1 inhibitor with IC50 value of 0.26 nM. |
| CSN12551 | Olmesartan medoxomil | 144689-63-4 | Olmesartan Medoxomil is a synthetic imidazole-derived angiotensin II receptor antagonist, acting as a prodrug with an antihypertensive property. |
| CSN12552 | Telmisartan | 144701-48-4 | Telmisartan is an angiotensin II receptor antagonist with Ki value of 3.7nM, used in the management of hypertension with elimination half-life of 24 hours. |
| CSN12553 | Candesartan cilexetil | 145040-37-5 | Candesartan Cilexetil is a benzimidazole-derived and competitive AT1 inhibitor with IC50 value of 0.26 nM. |
| CSN12575 | Ezetimibe | 163222-33-1 | Ezetimibe is a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. It's also a Niemann-Pick C1-like1 (NPC1L1) inhibitor and Nrf2 activator. |
| CSN12705 | Azilsartan medoxomil | 863031-21-4 | Azilsartan Medoxomil is an orally available angiotensin II type 1 (AT1) receptor antagonist with IC50 value of 2.6 nM. |
| CSN12720 | Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate | 211915-06-9 | Dabigatran etexilate, the active prodrug of dabigatran, is a selective inhibitor of thrombin with Ki of 4.5 nM. |
| CSN12758 | (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride | 364782-34-3 | Cinacalcet HCl is an orally active calcimimetic compound and represents a class of compounds for the treatment of hyperparathyroidism. |
| CSN12828 | Bardoxolone methyl | 218600-53-4 | Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) activator. |
| CSN12830 | BGP-15 | 66611-37-8 | BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury. |
| CSN12961 | Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate | 872728-81-9 | Dabigatran etexilate mesylate inhibits thrombin with Ki value of 4.5 nM. It is the prodrug of dabigatran. |
| CSN12970 | Vernakalant HCl | 748810-28-8 | Vernakalant HCl prolongs repolarization by blocking atrial potassium channels, it's a class III antiarrhythmics. |
| CSN12974 | Sitaxsentan sodium | 210421-74-2 | Sitaxsentan sodium has selectory antagonism of endothelin A (ETA) receptor with the IC50 and Ki value of 1.4 nM and 0.43 nM respectively. |
| CSN12647 | 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN12549 | 1-Benzhydryl-4-cinnamylpiperazine | 298-57-7 | Cinnarizine, an antihistamine, can block calcium channel and promote cerebral blood flow. It is used to treat post-trauma cerebral symptoms and cerebral arteriosclerosis. |
| CSN12923 | 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one | 73963-72-1 | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. |
| CSN12942 | Doxazosin mesylate | 77883-43-3 | Doxazosin mesylate is a selective α1-adrenergic receptor blocker, used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH). |
| CSN12869 | Nicorandil | 65141-46-0 | Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). |
| CSN12981 | Quinapril HCl | 82586-55-8 | Quinapril HCl is a prodrug-form ACE inhibitor with a Ki of 20 μM, usd for treatment for hypertension and congestive heart failure. |
| CSN12736 | Phenoxybenzamine HCl | 63-92-3 | Phenoxybenzamine HCl is a non-selective irreversible dibenzamine α adrenergic antagonist with antihypertensive and vasodilatory properties. |
| CSN12852 | Barnidipine HCl | 104757-53-1 | Barnidipine HCl is a calcium-channel blocker. |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN12933 | (3R,5R)-3,5-Dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-(((S)-2-methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid | 81093-37-0 | Pravastatin is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| CSN12369 | Betrixaban | 330942-05-7 | Betrixaban is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM (inhibition of Factor 10a). |
| CSN12947 | Fluvastatin | 93957-54-1 | Fluvastatin inhibits HMG-CoA reductase activity with IC50 of 8 nM. |
| CSN12339 | NS-1619 | 153587-01-0 | NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. |
| CSN12960 | Clevidipine | 167221-71-8 | Clevidipine is a short-acting dihydropyridine calcium channel antagonist with IC50 of 7.1 nM, it's under development for treatment of perioperative hypertension. |
| CSN12451 | Dobutamine HCl | 49745-95-1 | Dobutamine HCl is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. |
| CSN12596 | Amiodarone HCl | 19774-82-4 | Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
| CSN12884 | (-)-Sparteine sulfate pentahydrate | 6160-12-9 | (-)-Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. |
| CSN12975 | Sitaxsentan | 184036-34-8 | Sitaxsentan is a selective endothelin A (ETA) receptor antagonist. |
| CSN12653 | Nitrendipine | 39562-70-4 | Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM. |
| CSN12356 | Anacetrapib | 875446-37-0 | Anacetrapib is a potent, selective, reversible rhCETP and mutant CETP (C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. |
| CSN12734 | Argatroban | 74863-84-6 | Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant. |
| CSN12826 | (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol | 274693-27-5 | Ticagrelor is a reversibly and oral active P2Y12 receptor antagonist with Ki of 2 nM, also inhibits CYP2C9 and midazolam 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively. |
| CSN12844 | 2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride | 405911-17-3 | GW3965 HCl is a selective and non-steroidal LXR agonist with EC50 values of 190 and 30 nM for hLXRα and hLXRβ, respectively. |
| CSN12872 | Avosentan | 290815-26-8 | Avosentan is a potent, selective endothelin receptor (ETA receptor) antagonist. |
| CSN12874 | 3-Isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | 66085-59-4 | Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy. |
| CSN12900 | Edoxaban | 480449-70-5 | Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. |
